Long-term or recurrent antibiotic use during early life was associated with an increased risk of early-onset colorectalcancer and adenomas, according to an analysis of data. CRCSM
and adenomas, particularly in people with a variant in a specific gut microbiota regulatory gene, a new analysis found.Researchers analyzed data from UK Biobank participants who were recruited between 2006 and 2010 and were followed up to February 2022.
They evaluated associations between early-life factors and early-onset CRC risk overall, focusing on long-term and recurrent antibiotic use. The team also estimated associations between long-term and recurrent antibiotic use in early life and CRC risk by polygenic risk score using 127 CRC-related genetic variants, as well as a particular gut microbiota regulatory gene, fucosyltransferase 2 .The study included 113,256 participants. There were 165 early-onset CRC cases and 719 early-onset adenoma cases.
The researchers found a strong positive association between long-term and recurrent antibiotic use and adenomas, largely in patients with rs281377 TT and CT genotypes . Individuals with a high polygenic risk score were at higher risk of early-onset CRC , while those with low polygenic risk scores were not at higher risk . The association between antibiotic use and early-onset CRC risk by family history was also higher ."Our findings suggested that individuals with genetic risk factors who have experienced early-life antibiotics use on a long-term basis are probably at increased early-onset CRC risk," the authors concluded.
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