COVID-19 antibody discovery could explain long COVID

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COVID-19 antibody discovery could explain long COVID
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Researchers discover that the COVID-19 virus can trigger the production of 'abzymes' -- antibodies that act like enzymes -- which may explain why long COVID symptoms persist even after the infection is cleared.

Researchers discover that the COVID-19 virus can trigger the production of 'abzymes' -- antibodies that act like enzymes -- which may explain why long COVID symptoms persist even after the infection is cleared.

Doctors may be able to target these"abzymes" to stop their unwanted effects. If abzymes with rogue activities are also responsible for some of the features of long COVID, doctors could target the abzymes to treat the difficult and sometimes mysterious symptoms of COVID-19 and long COVID at the source, instead of merely treating the downstream symptoms.

Recently, other groups have found that some patients with long COVID have problems with their coagulation systems and with another system called"complement." Both the coagulation system and the complement system are controlled by enzymes in the body that cut other proteins to activate them.

Zeichner, who is developing a universal coronavirus vaccine, expects UVA's new findings will renew interest in abzymes in medical research. He also hopes his discovery will lead to better treatments for patients with both acute COVID-19 and long COVID. Zeichner is the McClemore Birdsong Professor in the University of Virginia School of Medicine's Departments of Pediatrics and Microbiology, Immunology and Cancer Biology; the director of the Pendleton Pediatric Infectious Disease Laboratory; and part of UVA Children's Child Health Research Center.

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