Mark G. Kris, MD, discusses perioperative therapy for locally advanced lung cancer and the potential implications for survival and cure.
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I know there's a huge temptation to say,"Well, you're going to have good results with osimertinib; it's EGFR-mutant disease, why give chemotherapy?" But clearly the chemotherapy improves outcomes. Please remember here that, yes, chemotherapy is difficult and it disrupts lifestyle absolutely. We're talking about cure here. By increasing the chance of cure, it really makes sense to recommend chemotherapy to every single patient.
But extrapolating from the data on giving a checkpoint inhibitor with chemotherapy and knowing about the safety of chemotherapy with osimertinib, I think we're going to see more and more that you're going to want to give chemotherapy with osimertinib upfront. I know that's a little bit ahead of the curve, but it can be done safely, there's good evidence of that, and it makes sense.
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