Contrary to a warning placed on labels for CART-T cancer therapies, use of these treatments does not appear to boost the odds for a secondary cancer later, a new study shows.
Center in New York City believe CAR-T may be safer in that regard than is now assumed, and warning labels may need to be revised.
“I worry that the warning labels may intimidate patients who receive this therapy, which may not be entirely founded," Rejeski said in a news release from the American Association forSociety, in CAR-T therapy, immune system T-cells "are taken from the patient's blood and are changed in the lab by adding a gene for a receptor T-cell cancer, one that isn't related to the B-cellHowever, Rejeski and others believe the FDA data does not take into account other patient risk factors...
Four of the trials compared outcomes for patients who received CAR-T therapy versus standard regimens. Rates of secondary cancers were similar regardless of treatment type: 5% of patients treated with CAR-T developed a new tumor compared to 4.9% of those who did not receive CAR-T. Furthermore, most of the new malignancies that arose during follow up were not T-cell specific, Rejeski's team found.T-cells were tested to see if they had any genetic relation to the T-cells used in the patients' CAR-T therapy. Only one such case tested positive, the researchers reported.
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