Scientists need a better understanding of the chemistry of radium to be able to target the isotope radium-223 (Ra-223) to cancer cells. Once delivered, Ra-223 can destroy those cells with alpha particles, a type of radiation.
therapy. Through experiments and computer-driven models, the researchers discovered that macropa is the strongest chelator for binding radium identified so far. They also gained information about how the structure and properties of these chelators affect how well they bind to radium.
The work determined that the Ra−macropa complex had a more stable bond than that of any other studied Ra complexes under normal biological conditions. The Ra−DOTA complex was only moderately stable when thewas present, but its stability increased under sodium-free conditions. The study showed that, as scientists already had thought, chelators form bonds with radium that are primarily ionic. That means highly charged chelators can form highly stable complexes.
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