Science, Space and Technology News 2024
Researchers at the University of Houston, led by Navin Varadarajan, have discovered a new subset of T cells, termed CD8-fit, which are associated with improved outcomes in T-cell therapies for cancer. Using a combination of the TIMING method and single-cell RNA sequencing, the team identified a molecular signature in these T cells that correlates with long-term positive clinical outcomes.
While T-cell immunotherapy has revolutionized cancer treatment, there is still much to learn. Unfortunately, not all patients respond to these therapies, so a better understanding of the properties of engineered T cells is necessary to improve clinical responses.by the laboratory of Navin Varadarajan, M.D. Anderson Professor in the William A. Brookshire Department of Chemical and Biomolecular Engineering.
“Chimeric antigen receptors T cells used for the treatment of B cell malignancies can identify T-cell subsets with superior clinical activity. Using infusion products of patients with large B cell lymphoma, we integrated functional profiling using TIMING with subcellular profiling and scRNA-seq to identify a signature of multifunctional CD8 T cells ,” said Rezvan.
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