Science, Space and Technology News 2023
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“GBM has an aggressive effect in part because of a milieu of immunosuppressive factors surrounding the tumor, which enable the tumor’s growth by preventing the immune system from entering and attacking it,” said corresponding author E. Antonio Chiocca, MD, PhD, Chair of the BWH Department of Neurosurgery. “This study showed that with a virus we designed, we can reshape this ‘immune desert’ into a pro-inflammatory environment.
Overall, the trial demonstrated the safety of CAN-3110 in 41 patients with high-grade gliomas, including 32 with recurrent GBM. The most serious adverse events were seizures in two participants. Notably, GBM participants who had pre-existing antibodies to HSV1 virus had a median overall survival of 14.2 months. In patients with pre-existing antibodies, the researchers saw markers of several changes in the tumor microenvironment associated with immune activation.
“Almost no immunotherapies for GBM have been able to increase immune infiltration to these tumors, but the virus studied here provoked a very reactive immune response with infiltration of tumor-killing T-cells,” Chiocca said. “That’s hard to do with GBM, so our findings are exciting and give us hope for our next steps.”Authorship: Co-first authors are Alexander L. Ling , Isaac H. Solomon , Ana Montalvo Landivar , and Hiroshi Nakashima . Mass General Brigham co-authors include Jared K.
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