Antidote for world’s most venomous animal potentially discovered by scientists
Warm Australian waters are home to the box jellyfish , which is considered to be one of the most venomous animals on the planet.
Flipping all the switchesThis work began in 2012, when we set out to determine what it was about box jellyfish venom molecules that made them so effective in causing pain and damage. Putting the evidence togetherThen using new DNA sequencing technologies , we identified which human genes had been switched off in our genome editing experiments.
So this helped us understand more about how the venom works – and maybe even how it causes pain. We are still looking at this particular pathway in more detail, but at the moment it doesn’t seem promising for a therapy.We found four of the top ten genes required for venom action were all part of a pathway that makes cholesterol in cells.
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