Patients with IBS-C and moderate to severe bloating achieved reductions in bloating after receiving plecanatide, but those with mild bloating showed no improvement.
for 12 weeks, but those with mild bloating showed no improvement. Decreased abdominal pain and increased bowel movement frequency occurred in both groups.Plecanatide has been approved by the US Food and Drug Administration for treating abdominal pain and constipation in people with IBS -C, and researchers aimed to gain a deeper understanding about the benefits of plecanatide in patients with IBS -C subgrouped by baseline bloating severity.
Patients were stratified into mild and moderate to severe bloating subgroups based on baseline bloating severity scores .At baseline, 23.1% experienced mild bloating, and 76.9% reported moderate to severe bloating. In the moderate to severe subgroup, plecanatide vs placebo led to a greater improvement in bloating severity were limitations. The authors also acknowledged that it was difficult to identify and assess the severity of bloating, as many patients use this term synonymously to describe abdominal distention.This study was supported by Salix Pharmaceuticals. Three authors declared serving as employees of Salix Pharmaceuticals.
Irritable Bowel Syndrome (IBS) IBS Bloating Abdominal Bloating Pain Management Abdominal Pain Abdominal Pain Constipation Costiveness Michigan Diarrhea Diarrhoea Board Certification Boards Board Recertification U.S. Food And Drug Administration United States Food And Drug Administration Fda
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