Alzheimer’s disease is the most prominent cause of dementia affecting millions of people worldwide. As the changes in brain function start around 10-20 years before the clinical onset of Alzheimer’s disease, there is a strong interest in the identification of early markers that can be predictive of
Researchers at the Karolinska Institute have identified astrocytes as a promising target for the early detection of Alzheimer’s disease due to their swift response to its progression. In a study published in, they explored the role of astrocytic α7nAChRs, a subunit of nicotinic acetylcholine receptors, in Alzheimer’s disease pathology and biomarkers.
In this context, the crosstalk between cholinergic signaling and reactive astrogliosis could hold the key to understanding the early responses of glial cells to brain pathology and injury. The landmark ‘Cholinergic Hypothesis of Alzheimer’s disease’ was proposed almost four decades ago, and paved the way for the development of cholinesterase inhibitors – so far, the gold-standard therapy for Alzheimer’s disease.
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