A retrospective study found a sex difference in patients with aortic stenosis treated with ARBs.
A retrospective study aimed to determine whether a sex-specific difference exists in the relationship between ARBs and the progression of disease in patients with aortic stenosis . The study included data from 1321 patients who had received aorticwith or without coronary bypass grafting. It found that among female patients, who tended to have more fibrosis than their male counterparts, those taking ARBs had lower fibrosis scores.
The study drew data from a large database of patients with severe aortic stenosis who had an aortic valve replacement between 2006 and 2013 at a hospital in Quebec. The 1321 patients included were divided into the following four groups, based on the severity of disease: Mild fibrosis and calcification, predominant fibrosis, predominant calcification, and severe fibrosis and calcification.
Thus, because the study was retrospective and included many patients with severe aortic stenosis, Carter-Storch noted that it is not clear if the medication itself caused the reduced fibrosis. He added that cardiologists should refrain from making clinical recommendations until randomized controlled trials are completed. "This is preliminary, but it's a promising finding.
In addition, women are underrepresented in cardiovascular disease research as a whole, according to Sandhu. "Cardiovascular disease in women remains understudied, underrecognized, underdiagnosed, and undertreated." More studies are needed to improve our understanding of sex differences in the manifestation and treatment of heart disease, she said.
Cardiovascular Risk CV Risk Factors Cardiovascular Risk Factors Cardiovascular Risk Management Cardiac Surgeries Cardiac Surgery Congenital Heart Disease Aortic Stenosis Stenosis Of The Aorta Valvar Aortic Stenosis Stenosis Pathologic Constriction Calcific Aortic Disease Hypertension Practice Management Revenue Aortic Valve Canada Cardiovascular Disease
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