The preponderance of evidence does not support the conclusion that aggressive cholesterol-lowering is associated with cognitive impairment or hemorrhagic stroke, a new statement concludes.
"The brain is the body's most cholesterol-rich organ, and some have questioned whether aggressive LDL-C lowering induces abnormal structural and functional changes," the writing group, led by Larry Goldstein, MD, chair, Department of Neurology, University of Kentucky, Lexington, points out.
The eight-member writing group used literature reviews, references to published clinical and epidemiology studies, clinical and public health guidelines, authoritative statements, and expert opinion to summarize the latest evidence and identify gaps in current knowledge.First, the available data"consistently" show that LDL-C lowering reduces the risk of atherosclerotic cardiovascular disease-related events in high-risk groups.
Third, the risk for hemorrhagic stroke associated with statin therapy in patients without a history of cerebrovascular disease is"small and consistently nonsignificant." They found no evidence that PCSK9 inhibitors or increases bleeding risk. Further, there is"no indication" that patients or populations with lifelong low LDL-C have enhanced vulnerability to hemorrhagic stroke, and there is"little evidence" that achieving very low levels of LDL-C increases that risk.
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
LA County Sheriff Luna: DA Gascon assures aggressive prosecution of suspect in deputy's ambush killingLos Angeles County Robert Luna is asking DA George Gascon to prosecute the suspected killer o his deputy
Read more »
Clit-Erally 22 Highly-Rated Sex Toys That Earned A Lot Of 5-Star ReviewsSimply clit-tastic.
Read more »
Ricki and the Flash (2015) | ScreenRantAll the latest movie news, movie trailers & reviews - and the same for TV, too.
Read more »