Treatment with adalimumab was associated with improvements in common hematologic abnormalities in patients with hidradenitis suppurativa, particularly in responders.
HS is a chronic inflammatory skin condition characterized by a high inflammatory burden and hematologic abnormalities such as anemia, leukocytosis, and thrombocytosis. Immunomodulatory therapy was previously found to improve hematologic abnormalities in a small
To evaluate whether adalimumab therapy was associated with clinical improvement and reductions in hematologic abnormalities, a post hoc analysis of two phase 3 randomized controlledof adalimumab, a tumor necrosis factor blocker, evaluated 633 patients with moderate to severe HS, randomized to receive 40-mg adalimumab weekly or placebo for 12 weeks.
Researchers identified 252 patients in the studies with at least one hematologic abnormality at baseline and divided them into four groups based on their treatment assignment and HS Clinical Response status at 12 weeks: Adalimumab responders and nonresponders and placebo responders and nonresponders .Among the 123 patients who received adalimumab, including nonresponders, significant improvements were observed in mean changes in hemoglobin levels , platelet count .
Skin And Soft Tissue Infection Anemia Anaemia Platelet Count PLT - Platelet Count Thrombocyte Count Platelets Thrombocytes Hemoglobin Hb Hemoglobin Hgb Hb - Hemoglobin Leukocytosis Thrombocytosis White Blood Cell Count Leukocyte Count WBC Count White Count Blood Grant Translational Research Translative Research Translational Science Tumor
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