Your patient's 'round face' might be the first clue that he or she has Cushing syndrome, but there are other symptoms as well. How can you accurately diagnose the condition?
"Moon face" is a term that's become popular on social media, used to describe people with unusually round faces who are purported to have high levels of cortisol. But the term"moon face" isn't new. It was actually coined in the 1930s by neurosurgeon Harvey Cushing, MD, who identified patients with a constellation of clinical characteristics — a condition that came to bear his name — which included rapidly developing facial adiposity.
An accurate diagnosis should be on the basis of signs and symptoms, biochemical screening, other laboratory testing, and diagnostic imaging."CS mostly presents as a combination of two or more features," Fleseriu stated. These include increased fat pads , skin changes, signs of protein catabolism, growth retardation and body weight increase in children, and metabolic dysregulations .
According to the 2021 guideline, this is"based on the assumption that patients with CS lose the normal circadian nadir of cortisol secretion."The authors noted that in healthy individuals, a supraphysiologic dexamethasone dose inhibits vasopressin and adrenocorticotropic hormone secretion, leading to decreased cortisol concentration.
CT evaluation of the neck, thoracic cavity, and abdomen to diagnose ectopic CS, including lung neuroendocrine tumors and bronchial neuroendocrine tumors
Cushing's Disease Hypercortisolism Hyperadrenocorticism Cushing Syndrome Cushing Disease Facial Otolaryngology ENT Specialty Head And Neck Surgery ENT Speciality Thyroid Disorder Thyroid Disease Thyroid Dysfunction Neuroendocrine Tumor Neuroendocrine Tumour NET Nets Neuroendocrine Tumor (NET) Neuroendocrine Tumors (Nets) Neuroendocrine Tumour (NET)
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