Soon after cholesterol and fat begin to accumulate on the lining of the blood vessels supplying the heart, the smooth muscle cells that provide strength and flexibility to the blood vessels start to grow and multiply. Scientists researching this phenomenon believe that the vascular smooth muscle
Heart disease is a leading cause of death worldwide. It is estimated that in the United States, 1 in 4 deaths are caused by heart disease. Factors that increase the risk of developing heart disease include high blood pressure, high cholesterol, smoking, diabetes, and obesity.
In states of good health, for example, the two cell types share messages about how it’s time for our blood vessels to dilate a little because we are exercising.
There are two fundamental ways cells come up with purine: One is to essentially make it from scratch, called de novo purine synthesis, and the other is recycling. “It takes away one of the building blocks of DNA,” says Ma. “The blood vessels remained normal. The lumen stayed open.” Huo’s lab also plans to examine when vascular disease is not present, whether smooth muscle cells instead opt to use purine recycling to meet the much lower demand for protein rather than the multistep production process, which includes ATIC.
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