49ers vs. Cardinals, Seahawks vs. Giants pick: NFL Week 5 odds, predictions

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49ers vs. Cardinals, Seahawks vs. Giants pick: NFL Week 5 odds, predictions
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Football handicapper Sean Treppedi is in his first season in The Post’s NFL Bettor’s Guide.

Malik Nabers catches a pass in the fourth quarter before being tackled by cornerback Jourdan Lewis during the Giants' Week 4 loss to the Cowboys.Gambling content 21+. The New York Post may receive an affiliate commission if you sign up through our links. Read ourWith the fickle week-to-week results of the NFL , each matchup should be considered in a vacuum — and when it comes to the Giants, their win against Cleveland followed by the valiant loss to Dallas shouldn’t be overvalued.

We can still be reassured by what Arizona’s offense is capable of despite the blowout loss to Washington. Kyler Murray is neck-and-neck with Brock Purdy in passer rating at 104.6 and 104.9, respectively, all while James Conner spearheads the ground game at 5.3 yards per carry. Besides, underdogs by four-plus points that lost by 28-plus points in the prior week have covered at a 62 percent rate in the past 20 years. San Francisco may have righted the ship against a monotonous New England team last week, but it remains plagued by injuries — which include George Kittle, Fred Warner and, of course, Christian McCaffrey.

How the bond between Jose Trevino and Austin Wells has made the Yankees' catching duo one of MLB's best

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