All this points to the need for novel, and more sensitive approaches to diabetes diagnosis and therapy.. This field of study looks at how our behaviours and surrounding environment may induce genetic changes that predispose us to certain diseases.. These molecules control which proteins are developed, and which proteins aren’t.
The study of genetic mechanisms such as miRNAs is known as epigenetics. This is an umbrella of various mechanisms revolving around genetic changes that may occur due to our habits and surrounding environment. These adverse genetic changes may subsequently result in increased risk of disease. We observed higher levels of the miRNAs in the prediabetic and diabetic groups, in comparison to the normal group. There was more of an increase in the prediabetic group versus the normal group. This told us that for some reason, people with early-stage diabetes have higher levels of these miRNAs. This could indicate that this is either a compensatory response by the body to curb the disease progression, or a knock-on effect of disease progression.
Our next question was: How well can miRNA expression analysis perform in identifying prediabetes and full-blown diabetes, in comparison to known and acknowledged tests?
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