The UK medicines regulator gave the so-called bivalent vaccine made by US drug company Moderna conditional approval as a booster for adults on Monday.
Moderna in June said trial data showed that when given as a fourth dose, the variant-adapted shot raised virus-neutralizing antibodies by eight-fold against Omicron. However, the correlation between neutralizing antibody levels and vaccine effectiveness against disease – in particular severe disease – remains unclear.
“What this bivalent vaccine gives us is a sharpened tool in our armoury to help protect us against this disease as the virus continues to evolve,” MHRA Chief Executive June Raine said in a statement. In contrast, the US Food and Drug Administration has said it will seek the specific inclusion of the newer BA.4 and BA.5 offshoots of Omicron in any new shots used domestically.
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