Third Covid-19 vaccine shot lifts response in transplant patients

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In a small study, a third of organ recipients who had no antibodies after their second dose developed them after a third dose

A vaccine booster shot could help beef up protection against Covid-19 for some organ transplant recipients, a group fearful their suppressed immune systems may leave them defenceless as pandemic restrictions end.

“It’s showing us that the immune systems of immunosuppressed patients can be activated,” said Dorry Segev, one of the researchers and a professor of surgery and epidemiology at the university. People in the study got different combinations of shots, some stuck with the same vaccine for their booster and some got a different vaccine. With the small size of the study, the researchers didn’t see signals on whether certain combinations worked better, Segev said.

In the Johns Hopkins study, researchers didn’t observe any anaphylactic reactions or neurological complications. One heart transplant recipient experienced a rejection in which she has found to have antibodies directed against her donated organ a week after her third dose, but she recovered and it’s uncertain whether the rejection was related to the vaccine, Segev said.

Antibodies don’t show the entire picture of immunity and other arms of the immune system could help protect patients if they get infected. Segev’s team is also studying the cellular immune response of patients who got a third shot and confirming that their antibody levels after the third dose are correlated with neutralising antibodies, he said.

 

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