SA studies suggest Omicron has higher ‘asymptomatic carriage’

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Preliminary findings from two South African clinical trials suggest the Omicron variant has a much higher rate of “asymptomatic carriage” than earlier variants, which could explain why it has spread so rapidly across the globe. Moneyweb Covid19

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Preliminary findings from two South African clinical trials suggest the Omicron coronavirus variant has a much higher rate of “asymptomatic carriage” than earlier variants, which could explain why it has spread so rapidly across the globe.

In the Ubuntu study evaluating the efficacy of Moderna’s Covid-19 vaccine in people living with HIV, 31% of 230 participants undergoing screening tested positive, with all 56 samples available for sequencing analysis verified to be Omicron. In a subgroup of the Sisonke trial evaluating the efficacy of Johnson & Johnson’s Covid-19 vaccine, the mean asymptomatic carriage rate rose to 16% during the Omicron period from 2.6% during the Beta and Delta outbreaks.

They added that the “higher asymptomatic carriage rate is likely a major factor in the rapid and widespread dissemination of the variant, even among populations with high prior rates of coronavirus infection”.

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