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Malaria drug tests under the spotlight after WHO warning

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An international trial to test whether the common malaria drug chloroquine can be used to prevent Covid-19 infection among healthy volunteers — which on Tuesday got final ethics and regulatory approvals in SA — will not be affected by the suspension of a trial treating hospitalised patients with a similar drug.

The Crown Coronation study will investigate whether chloroquine prevents infection among health-care workers and, secondly, whether it decreases the severity of infection — testing three different doses.

is testing whether hydroxychloroquine or combinations of three other experimental drugs could be effective treatments for Covid-19 among 3,500 patients in 17 countries. Crown Coronation study national co-principal investigator Prof Sinéad Delany-Moretlwe, director of research at the Wits Reproductive Health and HIV Institute in Johannesburg, said on Tuesday: “These data do not apply to the use of any [drug] regimen used in the ambulatory, out-of-hospital setting.”

 

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