Your Questions about the New COVID Booster Shots, Answered

9/16/2022 4:45:00 PM

New COVID booster vaccines built for the latest variants are here and should be more effective. But there are still some unknowns

New COVID booster vaccines built for the latest variants are here and should be more effective. But there are still some unknowns

New COVID booster vaccines built for the latest variants are here and should be more effective. But there are still some unknowns

A new generation of COVID booster shots are now available to most people 12 years of age and older in the U.| September 12, 2022 8:39 pm Note: The above segment misstates the school's health care approach.Data presented to the Centers for Disease Control and Prevention Sept.results from sequencing labs.

S.The Food and Drug Administration authorized new formulations of the Moderna and Pfizer-BioNTech COVID vaccines for use as a single booster dose just a few weeks ago.DePaul University has a new face on campus.That decision was quickly endorsed by an immunization advisory panel at the U.» READ MORE: Do I need the new COVID booster? And other questions you may have.S.Manuel, its 13th president.Centers for Disease Control and Prevention.It was 29% for the week of July 10, 28% for the week of July 17, 27% for the week of July 24, and 24% for the week of July 31.

The updated boosters target the newer, widely spread Omicron subvariants of the COVID-causing virus, BA.Now he’s setting big goals for the DePaul community.That doesn’t raise safety concerns, Jahre said, but it does leave uncertainty about how effective it’ll be in people.4 and BA.5, as well as the early 2020 form of the microbe, known as the ancestral strain.“A few times in higher education history have come out of such a severe sense of isolation and trauma that we could redefine models of quality going forward,” Manuel said.On the week ending on September 10, BA.Due to vaccination, natural immunity, or a combination of both, most people are much more protected against the more serious consequences of COVID than they were almost two years ago.5 was estimated to be responsible for 87.“The biggest goal is to find a design for DePaul to match the times coming out of COVID to design ourselves to be an asset to the city,” he said.28 and 12% for the week of Sept.

5 percent of news infections in the U.S..“Is the $3.This is the first change for the Pfizer and Moderna shots since they were introduced two years ago, when they contained only genetic material from the ancestral form of the virus.The new booster shots are expected to trigger a better immune response against the new subvariants.making sure that we still teach what is needed out there.Clinical studies of similar two-part COVID boosters, as well as mouse research with these specific formulations, suggest that will be the case.” The piece noted additional protection may be valuable to people with some health conditions and the elderly, but perhaps not for everyone 12 and older, who are now eligible to receive the bivalent shots.21, 2020, still remain among the worst in the country.

Still, some scientists point out we have no hard evidence the new shots will provide longer-lasting protection than previous boosters.About half of the DePaul attending population are students of color, and 87% of undergraduates receive federal aid, according to Data USA.That’s an issue because people are tired of frequent requests to get yet another shot.But the U.“In DePaul’s case, our tuition has increased 26% since 2013 but the amount of money that we put in from our own resources to help students afford that has increased by 77% at the same time,” he said.S.government is pushing for a rapid and wide rollout before an anticipated increase of cases in fall and winter months.Being new to Chicago, Manuel says he aims to listen to the community more, particularly students and faculty who might present new approaches to the redevelopment of DePaul.New York City has the highest death rate, at 496 deaths per 100,000 people, followed by Mississippi at 430.

“It comes at a fortuitous time,” says epidemiologist Ali Khan, dean of the University of Nebraska Medical Center College of Public Health.“As people congregate closer together in winter months, they’re more likely to spread microbes between them.Thanks to our sponsors:.So it’s great timing for what is expected to be a fall wave of cases.” Here is what we know about the makeup, effectiveness and safety of the new vaccine formulations, which are known as bivalent shots because they contain components of two versions of the virus.We’ll also cover a few things that scientists are still trying to figure out.Related: Yuma agriculture lab steps up to help fight, prevent COVID-19 outbreaks Arizona is still behind the U.

What are the updated boosters made of? The Pfizer-BioNTech and Moderna COVID vaccines contain snippets of viral genetic material called mRNA.Once injected, it can’t create a whole virus, but it does tell cells to build one isolated piece, the infamous spike protein found on the surface of SARS-CoV-2.When the human immune system detects that protein, it starts to produce antibodies and activate other immune cells that can fight the actual virus.The updated boosters contain mRNA instructions for both the ancestral spike protein and the one on Omicron BA.4 and BA.The state reported over 5.

5.(The protein from those two subvariants is extremely similar.) This is why the new shots induce a broader immune response.All of the other ingredients—such as lipids, salts and acids, which help protect the mRNA and deliver it to our cells, balance acidity and maintain the stability of the vaccine—haven’t changed from the original formulation.The overall dose of each updated booster is also the same as the original boosters.Arizona's rate of fully vaccinated people out of the total population was 63.

“This is part of the benefit of having an mRNA vaccine, where you can change only the variants and keep everything else consistent,” says Gigi Gronvall, a senior scholar at the Johns Hopkins Center for Health Security.“I wish that we had had these updated vaccines earlier.” How effective are the boosters? The FDA authorization was based on clinical trials of earlier versions of bivalent boosters (made with components of previous SARS-CoV-2 variants), mouse studies of the current bivalent boosters and real-world experience with the COVID mRNA vaccines.Clinical trials of these newest formulations are still being conducted, so their data did not figure into the go-ahead decision.But many scientists contend that the existing studies provide ample evidence of effectiveness.S.

In a clinical preprint study evaluating one of Moderna’s earlier bivalent booster versions—which was made with the ancestral form and the original Omicron variant, called BA.1—participants who received the booster had a 7.1-fold rise in neutralizing antibody levels against Omicron.The ones who received the ancestral-only booster had a smaller, 3.8-fold rise in neutralizing antibody levels.Out of people ages 5 and older, 67.

An advantage was also seen in neutralizing antibody levels against Omicron BA.4 and BA.5.A similar result was achieved by an earlier bivalent booster developed by Pfizer and BioNTech.It led to a 9.1% of fully vaccinated Arizonans over the age of 18 had received a first booster shot as of Sept.

1-fold rise in neutralizing antibody levels against the original form of Omicron, compared with a 5.8-fold rise obtained by the ancestral-only booster.A smaller advantage was seen in neutralizing antibody levels against BA.4 and BA.5.Cases by county: 1,421,340 in Maricopa; 289,898 in Pima; 146,915 in Pinal; 67,559 in Yuma; 63,455 in Mohave; 54,789 in Yavapai; 49,418 in Coconino; 43,986 in Navajo; 35,943 in Cochise; 31,066 in Apache; 19,736 in Gila; 18,489 in Santa Cruz; 13,368 in Graham; 5,741 in La Paz; and 2,456 in Greenlee, according to state numbers.

The mouse studies of the new bivalent boosters showed they also increased neutralizing antibody levels, compared with earlier boosters.This strategy of using previous clinical data and animal studies is what has been done with influenza vaccines for many years, notes immunologist Alessandro Sette of the La Jolla Institute for Immunology.Flu shots are updated to target newer influenza strains without additional clinical studies.When it comes to the new COVID shots, “obviously, if more data was available, specifically immunogenicity data in humans, that would be better,” Sette says.“But I still think it’s a reasonable path to take.average rate since the pandemic began is 28,660 cases per 100,000 people as of Tuesday,.

” Like Gronvall, his confidence is buoyed because the overall structure of the updated boosters is very similar to the original ones.Though Sette is reassured, some other experts believe that the lack of human data about these particular shots could turn into a problem when it comes to building public trust.Epidemiologist Michael Osterholm, director of the Center for Infectious Disease Research and Policy (CIDRAP) at the University of Minnesota, says he worries that if people have a concern about the safety or efficacy of the updated boosters, they might not get the shots.“I was hoping we would have immunogenicity data in humans to be able to say that, actually, the immune response is better or at least similar to the current vaccine,” he adds.Are the new shots safe? Osterholm himself is confident about safety.

“I do not believe that we need any additional safety data.We have no reason to believe that there’s going to be any difference in safety with regards to the current vaccines versus the ones we’ve been using,” he says.Clinical trials of the earlier bivalent booster versions show that they have a risk profile very much like the original vaccines and boosters.The clinical study that evaluated the earlier version of Moderna’s bivalent booster showed that the most commonly reported side effects were typical, including pain, redness and swelling at the injection site, fatigue, and some nausea and fever.An early version of a bivalent shot from Pfizer and BioNTech had a similar profile.

Overall, the mRNA vaccines have been administered to millions of people around the world, says epidemiologist William Moss, executive director of the International Vaccine Access Center at the Johns Hopkins Bloomberg School of Public Health.“We may have more information on these vaccines than almost any other vaccine,” he says.“I’m comfortable that this is sufficient evidence to make a policy decision like this.” Who is eligible? First, you must be fully vaccinated.For most people, that means you have received two primary doses of vaccines made by Moderna, Novavax, or Pfizer and BioNTech or one primary dose of the shot made by Johnson & Johnson’s subsidiary Janssen.

At least two months must have passed since you completed this primary vaccination series or received your most recent booster.Under those conditions, people age 18 and older are eligible for the new booster from Moderna, and people age 12 and older are eligible for the one from Pfizer and BioNTech.The situation is slightly different if you are immunocompromised—for instance, if you have a weakened immune system because of a current cancer treatment or an organ transplant.In that case, you must have received three primary doses of Moderna or Pfizer-BioNTech, two primary doses of Novavax or one primary dose of Janssen plus an additional dose of Pfizer-BioNTech or Moderna.No booster is required to be considered fully vaccinated.

Although children under age 12 are not eligible yet, this could change in the upcoming months.Pfizer and BioNTech expect to file an FDA submission for children ages five to 11 sometime in October, the companies said in late August.There are a few reasons that could explain the delay, Khan notes.“We know, for example, that children require different doses than adults,” he says, adding that there is also more scrutiny and rigor around authorizing vaccination for kids.People who are not sure if they are up-to-date with their vaccines can use a CDC tool to determine their eligibility for a booster (just click on the button “Find Out When to Get a Booster” and answer a few questions to get a personalized recommendation).

You can search for locations offering the updated boosters here.Do you need a booster if you were recently infected? Moss notes that the status of an individual’s COVID immunity results from a combination of factors, including the number of vaccine doses they received, if they were infected with the virus and the timing of all those events.“We can’t test everyone to see where they are in terms of their antibodies against BA.5 and decide who needs and who does not need vaccination based on that,” Moss says.“I would say that if someone knows they were infected with BA.

5—and that’s a lot of people—they should probably still get the booster.” He notes that although people who have been infected with Omicron may retain some natural immunity to the virus, they will probably get additional protection from the booster.Such people should consider waiting three months postinfection before getting the new shot, according to CDC recommendations, and people with a current COVID infection should wait until they are fully recovered.Highly vulnerable groups, such as older adults or the immunocompromised, will likely benefit the most, Moss adds.Are there other lingering uncertainties? The ancestral version of the virus that causes COVID, SARS-CoV-2, is no longer circulating, crowded out by more successful variants such as Delta and Omicron.

So some experts wonder why it is still in the recipe of the updated boosters.That question was raised in a recent preprint paper that hasn’t been peer-reviewed yet.The article was written by immunologist Rafi Ahmed, director of the Emory University Vaccine Center, and his colleagues.“It is highly unlikely that a new variant will emerge from the [ancestral] virus.From that perspective, boosting with [it] doesn’t make much sense,” Ahmed says.

“The other issue, which I’m surprised that not many people are discussing, is that when you combine the two, you reduce the dose of Omicron.” The original Moderna booster, for example, had a 50-microgram dose.The updated booster contains 25 micrograms of the original-virus-based vaccine and 25 micrograms of the Omicron BA.4/BA.5 vaccine.

“So you’re reducing the vaccine dose, which is always a concern that it could be less effective,” Ahmed says.Another uncertainty about the updated boosters is how long their protection will last.Achieving durable immunity from vaccines is one of the biggest challenges at the moment, Osterholm notes.Studies suggest that the protection conferred by the original mRNA booster against Omicron wanes after a few months, which is why we’ve needed repeated boosters.His group at CIDRAP is leading an effort to create a roadmap for COVID vaccine development, which includes efforts to make the immunity from shots last longer.

“I think one day the vaccines that we have now will be seen as having been very important,” he says.“But they’ll be replaced, hopefully, by vaccines that can give us more durable protection over time and [against] a wider range of variants.”.

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The best thing you can do is stay away from them I hate website cookies… I don't care what you think you know. I care about what you do not know. We are the pure bloods. Keep your graphene oxide bioweapon. zombieapocalypse Were they tested on more than 8 mice?...please tell me at least 50 mice were used in the experiment.

Can one become the infected from a direct bite from a bat? Bitten about a year ago by desmodus d. TRVP1 gain of function hypothesis... I do not trust the vaccine industry at this point , the gov and the 'scientific community' have lied to the country so often there is little confidence now. ...so not ARE more effective but rather 'should be' more effective...cuz Science™️

Get in line! Free gifts with every jab! We live in an unscientific age. Looking at comments here says our schools are failing and we want to teach everyone a lesson. DEMOCIDE

New DePaul University President Talks COVID Impact, Tuition GoalsPresident Robert L. Manuel was the former president of the University of Indianapolis and an administrator at Georgetown and New York University. Now, he’s setting big goals for the DePaul community.

Some? 🤡 There should be no unknowns! The government should be more concerned about boosting the economy. Hard pass. Should? Science confirmed causative factors for Neurovascular Diseases Multiple Sclerosis and Covid 19 involve Chronic Cerebrospinal Venous Insufficiency (CCSVI) yet to be fully understood pmm and environmental issues such as infections or food/vitamin nourishment!

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The tragedies of 9/11 and COVID-19 gave me a new appreciation for freedomI received the Freedom Award from former N.Y. Gov. Pataki this year on 9/11 because of my advocacy for families whose loved ones died in nursing homes from COVID-19. And you wouldn’t politicised it like the left does. Because you have integrity and respect for the fallen on 9/11

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