What Are the Possible Side Effects of the Omicron-Specific COVID-19 Booster Shots?

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With the arrival of the long-awaited COVID-19 booster shots geared to target BA.4 and BA.5 omicron subvariants, many may be curious about its possible side effects.

That's a familiar list: It's the same group of side effects that came with the original formulations. But notably, in those clinical trials, the severity of the side effects was very mild.

Pfizer's trial found that about 52% of participants that received the BA.1 shot experienced mild pain at the injection site, 8% experienced moderate pain and only 0.3% experienced severe pain. Roughly 26% of participants experienced a mild or moderate headache, while only 0.3% experienced a severe one.

Moderna's trial found that nearly 59% of participants experienced fatigue, but only about 4% experienced that at a Grade 3 level, which is defined as significant fatigue that prevents daily activity. Severe side effects are"generally" most common after receiving a second dose of a vaccine, not after receiving a third or fourth dose, says Offit. You're only eligible for the new boosters if you've completed a primary vaccination series, meaning most people will have already received at least two doses ahead of time.. The new shots have the same dosage amounts as the original vaccines, which further suggests that their safety profiles could be similar, Offit says.


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When Omicron first came to New York, if it was controlled in time, we would not be worried about the side effects of the vaccine now.

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