What About a Booster Shot Now?

Here’s what we know about potential COVID booster shots and who might be first in line to get them

7/29/2021 12:04:00 AM

Here’s what we know about potential COVID booster shots and who might be first in line to get them

With Delta circulating, the question of whether more shots are needed has taken on new urgency. Here’s what we know.

What does the science say about immunity? It’s difficult to say just how long vaccine-induced immunity will last given the relatively short time that the COVID vaccines have been tested in people. Early research indicates it could last for several months or a couple of years, but several recent studies have found that antibody levels fade over time. Executives from Pfizer, Moderna, and Johnson & Johnson — the three COVID-19 vaccines authorized for use in the U.S. — have all said their company’s data suggests people will eventually need a booster following their first series of vaccinations in order to continue to fend off the virus. It’s not unusual for vaccines to require multiple doses spaced out over time, such as those for measles, mumps, and rubella administered to children.

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Pfizer shared preliminary data from lab tests recently that suggests a third dose of its shot is associated with a five-fold increase in antibodies in people between the ages of 18 to 55 after their second dose; for those between 65 and 85, it’s 11-fold. The company plans to submit its application for booster approval to U.S. regulators in August. Moderna is also looking into booster doses of its shot but has yet to release data on any booster studies.

New data also suggests that COVID-19 vaccines may be taking a hit in efficacy when it comes to the highly transmissible Delta variant. For instance, a study from researchers at Public Health England last week found the Pfizer shot is 88 percent effective at preventing symptomatic COVID against Delta versus 93.7 percent against the original virus strain. Another study found that the Moderna vaccine was 72 percent effective against the Delta variant after one dose compared to 78 percent, while the one-shot adenovirus AstraZeneca shot was just 67 percent effective. While they might not prevent all infections, vaccines still dramatically reduce hospitalizations and deaths to almost zero. headtopics.com

What do the experts think? Anthony Fauci, the nation’s leading infectious disease specialist, told CNN’s State of the Union recently that a booster shot “might likely happen” for certain Americans who fail to mount a strong defense against the coronavirus after vaccination: “Namely, people who have suppressed immune systems, those who are transplant patients, cancer chemotherapy, autoimmune diseases, that are on immunosuppressant regimens,” he said. That’s about 2.7 percent of the U.S. population, according to CDC’s advisory committee meeting held last week to discuss whether an additional shot could significantly boost the chances that a person with a weakened immune system will have a protective response. Among immunosuppressed patients who had no detectable antibody response after two doses, 33 percent to 50 percent developed an antibody response after receiving a third dose, according to CDC officials at the meeting. Booster shots for adults with impaired immune systems are already under way in Israel.

To that end, Pfizer reported on Friday that the U.S. government purchased 200 million more doses of their COVID-19 shots, should booster shots be widely administered later this year.Still, there’s been disagreement about how necessary COVID-19 booster shots are. When Pfizer made waves in July about a booster shot, the Centers for Disease Control and Prevention and the Food and Drug Administration responded with a joint statement that fully vaccinated Americans “do not need a booster shot at this time.” The same month, the World Health Organization’s top vaccine doctor, Dr. Kate O’Brien, said the group doesn’t have “enough information to provide a recommendation at this point.”

But the consensus seems to be shifting given the emergence of the ultra-transmissible Delta variant. “It’s easier for this Delta variant to overwhelm low antibody levels, and that’s why we were considering whether or not some people might need boosters,” Scott Gottlieb, the FDA’s former commissioner, told CBS Face the Nation on Sunday.

In the rare instances where vaccinated people contract the Delta variant, new data finds they have a similar amount of virus particles in the passage behind their nasal cavity as unvaccinated people — whose levels are 1,000 times greater than those detected in people infected with earlier variants of the coronavirus. The thinking is that this high viral load among infected vaccinated people means they are capable of transmitting the virus to others. headtopics.com

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Paywall for a Covid article. Stay classy. They know nothing of the booster injections or the other 2 it’s all experimental I recently did this. Do not want anymore.

Citing New Data, Pfizer Outlines Case for Booster ShotsPfizer offered new evidence on Wednesday in support of booster shots of its potent vaccine, reporting that the vaccine’s power wanes slightly over time but may be improved with a third dose. The new data, which have not yet been peer-reviewed nor published in a scientific journal, nonetheless confirm that the two-dose vaccine offers potent protection against the coronavirus. Whether booster shots will be widely needed is far from settled, the subject of heated debate among scientists. So far, fe Fuck that & that’s why we don’t be getting it yet!

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