US researchers test pig-to-human transplant in donated body

U.S. researchers are reporting the latest in a string of experiments in the quest to save human lives with organs from genetically modified pigs. This time, in a step-by-step rehearsal, Alabama surgeons transplanted pig kidneys into a donated body.

Technology, Science

1/20/2022 9:31:00 PM

U.S. researchers are reporting the latest in a string of experiments in the quest to save human lives with organs from genetically modified pigs. This time, in a step-by-step rehearsal, Alabama surgeons transplanted pig kidneys into a donated body.

Researchers on Thursday reported the latest in a surprising string of experiments in the quest to save human lives with organs from genetically modified pigs. This time around, surgeons in Alabama transplanted a pig’s kidneys into a brain-dead man — a step-by-step rehearsal for an operation they hope to try in living patients possibly later this year.

ADVERTISEMENTBut scientists still needed to learn more about how to test such transplants without risking a patient’s life. With the help of a family who donated a loved one’s body for science, Locke mimicked the way human organ transplants are done — from removing the pig “donor” kidneys to sewing them inside the deceased man’s abdomen.

For a little over three days, until the man’s body was removed from life support, the pair of pig kidneys survived with no sign of immediate rejection, her team reported Thursday in the American Journal of Transplantation.That was only one of several key findings. Locke said it wasn’t clear if delicate pig kidney blood vessels could withstand the pounding force of human blood pressure -- but they did. One kidney was damaged during removal from the pig and didn’t work properly but the other rapidly started producing urine as a kidney should. No pig viruses were transmitted to the recipient, and no pig cells were found in his bloodstream.

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Clinical-Grade Pig Kidney Transplanted Into Human Patient in Scientific FirstFor only the second time ever – and the first involving a clinical-grade organ – a genetically modified pig kidney has successfully been transplanted into a brain-dead human body, in a milestone example of xenotransplantation. wow and alotbetterthandoom but repair and preservetheorigianl why 😭 Hi, I am a structural engineer from Iran who have many ideas. I have summarized some of my ideas on my twitter(I suggest look at the idea of generating electricity by gravity). I want to work with companies and investors. Do you want to cooperate?

Doctors Transplant Two Pig Kidneys at Once Into a HumanIt's the latest experiment to suggest that pig-to-human transplantation may not be too far off from reality. Indian doc got even Lungs done, 24years back. Did the pig have anything to say about it?

Pig Kidneys Transplanted to Human in Milestone ExperimentTwo weeks ago, doctors in Baltimore reported completing the first successful transfer of a pig heart into a living human patient. Now pig kidneys might be just around the corner. I am interested in the full report Coming up next… Pig dicks. I'd prefer the pig live and the human die.

Double pig kidney transplant successfully performed in brain-dead patientThe experiment was intended to assess the safety of such transplants, prior to them being tested in clinical trials .

5 science experiments kids can do on themselves'Physically doing something gets people more excited than just reading about it' Here are some activities to help kids learn how the human body works ArtsyBrigadier 🤷🏾‍♀️ In the name of God!

Genetically modified pig kidneys transplanted into a brain-dead personTwo pig kidneys genetically edited to prevent rejection by the immune system have been transplanted into a brain-dead man in the US as a first step towards treating patients Quite the experiment. Add *that* one to the donor card. positiv07652695 Another way to exploit innocent beings with the intelligence of small children. 😤 Sounds rather opportunistic in a rather unsettling way but ok…..

First aid flights arrive in Tonga after big volcano eruption ADVERTISEMENT But scientists still needed to learn more about how to test such transplants without risking a patient’s life. With the help of a family who donated a loved one’s body for science, Locke mimicked the way human organ transplants are done — from removing the pig “donor” kidneys to sewing them inside the deceased man’s abdomen. For a little over three days, until the man’s body was removed from life support, the pair of pig kidneys survived with no sign of immediate rejection, her team reported Thursday in the American Journal of Transplantation. That was only one of several key findings. Locke said it wasn’t clear if delicate pig kidney blood vessels could withstand the pounding force of human blood pressure -- but they did. One kidney was damaged during removal from the pig and didn’t work properly but the other rapidly started producing urine as a kidney should. No pig viruses were transmitted to the recipient, and no pig cells were found in his bloodstream. But Locke said the kidney experiment could have more far-reaching impact -- because it shows that a brain-dead body can be a much-needed human model to test potential new medical treatments. The research was conducted in September after Jim Parsons, a 57-year-old Alabama man, was declared brain-dead from a dirt bike racing accident. After hearing this kind of research “had the potential to save hundreds of thousands of lives, we knew without a doubt that that was something that Jim would have definitely put his seal of approval on,” said Julie O’Hara, Parsons’ ex-wife. ADVERTISEMENT The need for another source of organs is huge: While more than 41,000 transplants were performed in the U.S. last year, a record, more than 100,000 people remain on the national waiting list. Thousands die every year before getting an organ and thousands more never even get added to the list, considered too much of a long shot. Animal-to-human transplants, what’s called xenotransplantation, have been attempted without success for decades. People’s immune systems almost instantly attack the foreign tissue. But scientists now have new techniques to edit pig genes so their organs are more human-like — and some are anxious to try again. The recent string of pig experiments “is a big step forward,” said Dr. David Kaczorowski of the University of Pittsburgh Medical Center. Moving on to first-stage trials in potentially dozens of people is “becoming more and more feasible.” A heart transplant surgeon, Kaczorowski has done experiments testing pig organs in non-human primates that helped pave the way but “there are only things we can learn by transplanting them into humans.” Hurdles remain before formal testing in people begins, including deciding who would qualify to test a pig organ, said Karen Maschke, a research scholar at the Hastings Center who will help develop ethics and policy recommendations for the first clinical trials under a grant from the National Institutes of Health. Scientists also still have much to learn about how long pig organs survive and how best to genetically alter them, cautioned Dr. Robert Montgomery of NYU Langone Health, who led that center’s kidney experiments in the fall. “I think different organs will require different genetic modifications,” he said in an email. For the newest kidney experiment, UAB teamed with Revivicor, the subsidiary of United Therapeutics that also provided organs for the recent heart transplant in Maryland and the kidney experiment in New York. Company scientists made 10 genetic changes to these pigs, knocking out some genes that trigger a human immune attack and make the animals’ organs grow too large — and adding some human genes so the organs look less foreign to people’s immune systems. Then there are practical questions such as how to minimize time spent getting pig organs to their destination. UAB housed the altered pigs in a germ-free facility in Birmingham complete with an operating room-like space to remove the organs and ready them for transplant. Revivicor chief scientific officer David Ayares said future plans include building more such facilities near transplant centers. ___ The Associated Press Health & Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. AP NEWS