Upadacitinib Provides Rapid Relief in Crohn's Disease

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Patients with Crohn's disease achieved rapid symptom relief with upadacitinib, including those with prior biologic failure.

improved soft/liquid stool frequency and abdominal pain scores within the first week of treatment in patients with moderate to severeResearchers conducted a post hoc analysis of pooled data from two phase 3 12-week induction trials — U-EXCEL and U-EXCEED — to evaluate symptom relief in patients with Crohn's disease. U-EXCEL included patients with or without prior biologic failure; U-EXCEED included patients with prior biologic failure only.

Overall, 1021 patients aged 18-75 years with a mean daily very soft or liquid SF of ≥ 4, APS of ≥ 2, a Simple Endoscopic Score for Crohn's disease of ≥ 6, and with or without prior biologic failure received once-daily 45 mg upadacitinib or placebo . Daily diary data were used to analyze any improvement in SF and APS for the first 15 days of starting treatment with upadacitinib or placebo.Patients who achieved SF/APS clinical response after 12 weeks were randomized to a maintenance trial — U-ENDURE — in which they received once-daily 15 mg upadacitinib, 30 mg upadacitinib, or placebo for 52 weeks.


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