U.S. surgeons successfully test pig kidney transplant in human patient

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WARNING - GRAPHIC CONTENT: For the first time, a kidney from a pig has been transplanted into a human without triggering immediate rejection by the patient's immune system

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Test results of the transplanted kidney's function "looked pretty normal," said transplant surgeon Dr. Robert Montgomery, who led the study.

In the United States, nearly 107,000 people are presently waiting for organ transplants, including more than 90,000 awaiting a kidney, according to the United Network for Organ Sharing. Wait times for a kidney average three-to-five years. Montgomery's team theorized that knocking out the pig gene for a carbohydrate that triggers rejection - a sugar molecule, or glycan, called alpha-gal - would prevent the problem.Revivicor unit. It was approved by the U.S. Food and Drug Administration in December 2020, for use as food for people with a meat allergy and as a potential source of human therapeutics.

Other researchers are considering whether GalSafe pigs can be sources of everything from heart valves to skin grafts for human patients.experiment should pave the way for trials in patients with end-stage kidney failure, possibly in the next year or two, said Montgomery, himself a heart transplant recipient. Those trials might test the approach as a short-term solution for critically ill patients until a human kidney becomes available, or as a permanent graft.

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