The 3rd Leading Global Cause of Death Is Likely Not What You Think, New Study Reveals

) and 88 microbe-drug combinations from 204 countries. This ended up covering 471 million records of infection, which they then used to create statistical models to estimate the scale of antimicrobial resistance.

The team explored two counterfactual scenarios. In the first, all drug-resistant infections were replaced with no infections, which the team explained is the number of deathsIn the second scenario, they replaced all drug-resistant infections with drug-susceptible infections, leading to an estimation of deaths directly caused by antimicrobial resistance.

The team concluded that in 2019, 4.95 million deaths were associated with drug-resistant bacterial infections, of which 1.27 million deaths were directly caused by antimicrobial resistance – a huge burden in all areas of the world, but particularly impacting low- and middle-income countries.These calculations suggested that only stroke and heart disease caused more deaths than antimicrobial resistance that year.

The authors note that, to their knowledge, this is the first time such a global estimate has been carried out at all. Because there are gaps in data from some parts of the world, and serious difficulties in carrying out the surveillance of antimicrobial resistance, there are some limitations to their modelling. But the conclusion is clear: we have a major global health problem."The threat of antimicrobial resistance has long been signaled.

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