at the University of California, San Diego, and their colleagues have developed a new form of CRISPR that can more efficiently insert correct DNA sequences at the site of a mutation, with fewer off-target effects.
The method uses a variant of the Cas9 enzyme called a nickase, which only cuts one strand of the DNA double helix. “We found that ‘softly’ nicking, or cutting, one strand of the DNA is even more efficient than making a clean double-stranded break,” says Bier.The researchers tested the approach in fruit flies that had a mutation that turned their eyes white instead of red.
The team didn’t introduce any extra pieces of DNA as a template for the cell to correct the mutation on the chromosome, so the molecular machinery must have used the other chromosome – inherited from the other parent – as a template. The team was able to confirm this was the case. “There’s accumulating evidence that when you create damage to one chromosome in a mammalian cell, then that somehow recruits the other chromosome. Then the region that’s broken gets the Band-Aid from the other chromosome,” says Bier.
This would give relief to sufferers of genetic disorders.
why was I neutered please tell me
New tech👨💻👨💻
It’s getting better all the time!
inside_cupboard I have absolutely no idea what that means but it sounds very promising …
Amazing!
Now there is a relief.. no fanks.
What is softer form
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