Ma et al. take a novel approach to an important problem of host cell susceptibility to HIV. They tackle an understudied area of glycan effects on HIV infection using a new method they developed called CyTOF-lec. This method allows single cell detection of infected cells when using a reporter virus for infection. Importantly, the authors go to considerable trouble to use biologically relevant systems, including a transmitted virus and tonsil, endometrial and peripheral T cells.
As requested, we have now added to Figure S1A tSNE plots of the immune cells colored by intensities of each of the lectins annotated by the major subsets. Did the authors perform replicates and quantify changes caused by Sialidase treatment? Please indicate the number of replicates The tonsil specimens were run in different batches from the endometrial and blood specimens, so we cannot formally exclude that the lower staining is due to batch effects. That being said, given the consistency of the lower staining by some of the lectins, and not other CyTOF protein-based markers, we believe that tonsils may indeed express lower levels of some of the glycans .
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