She wrote to a scientist about her fatigue. It inspired a breakthrough.

  • 📰 washingtonpost
  • ⏱ Reading Time:
  • 55 sec. here
  • 2 min. at publisher
  • 📊 Quality Score:
  • News: 25%
  • Publisher: 72%

United States Headlines News

United States Latest News,United States Headlines

Her dogged efforts lead to a new scientific discovery that may help many others with chronically fatiguing illnesses, including long covid.

That doctor found a marker for autoimmune diseases in Twinam’s blood. And yet, none of the proposed diagnoses fully fit. “Fatigue was my primary complaint, sometimes my only complaint,” says Twinam, who’d had a bout of suspected mononucleosis in high school that left her exhausted for months. “But no one knew what to do.”

“We’re very excited about trying” drugs to treat the problem identified in Twinam, said Paul Hwang, an NIH researcher who led the work.The red flags that Twinam had an unrecognized chronic illness began after her suspected case of mono in high school. She says she feels she never fully recovered. One big tell: In college, after exercising, Twinam would not experience an endorphin rush. Instead, she told her friends she “felt like garbage.

Twinam began a message to Hwang that proved pivotal: “I read with interest your recent article on inhibiting mitochondrial respiration in a mouse model of Li-Fraumeni Syndrome.” Hwang brought Twinam to Bethesda in 2017. During a battery of tests, a curious result popped up. Twinam’s calf muscle took a long time to replenish an energy-carrying molecule after a short exercise session. In other patients with Li-Fraumeni syndrome, this molecule regenerates in an average of 35 seconds. In Twinam, it took 80 seconds.Puzzled, Hwang flew Twinam’s brother and father to Maryland, as they both also carried a gene for Li-Fraumeni.

 

Thank you for your comment. Your comment will be published after being reviewed.
Please try again later.
We have summarized this news so that you can read it quickly. If you are interested in the news, you can read the full text here. Read more:

 /  🏆 95. in US

United States Latest News, United States Headlines

Similar News:You can also read news stories similar to this one that we have collected from other news sources.

She had the urge to write and so she did, in her 90sHilda Lassalette worried a little about divulging her age when she began writing a romance novel. She shouldn’t have worried.
Source: ladailynews - 🏆 332. / 59 Read more »

Watch: Chinese Girl Picks A Date Based On Their Tomato EggShe knew what was up when she picked the winner
Source: BuzzFeed - 🏆 730. / 51 Read more »

Dear Abby: She was offended that I called her son’s behavior creepyPlus: Everyone knows she’s living with him, but she lies about it to me.
Source: mercnews - 🏆 88. / 68 Read more »

Ask Amy: Fiancée still lives with her exDear Amy: She lives with the guy she has been with for 15 years. She has two children with him. They are not married and she told me there are no feelings or intimacy between them – and I believe that. But she still sleeps in the same bed with him.
Source: chicagotribune - 🏆 8. / 91 Read more »

Inside ‘Love Island USA’ winner Hannah Wright’s new friendship with Ariana Madix“She’s just so cool, she’s just so personable and she’s so amazing in person, too,” Wright gushes of Madix on Page Six’s “Virtual Reali-Tea” podcast.
Source: PageSix - 🏆 320. / 59 Read more »

Subway-riding snake freaks out New Yorkers: ‘I was shaking’One rattled resident was so frightened by an encounter with the transit-riding reptile, that when she reported the sighting to cops they thought she had been mugged, she told The Post.
Source: nypost - 🏆 91. / 67 Read more »