Researchers have managed to extend the lifespan of roundworms by five hundred percent—equivalent to a human living for four or five centuries.by genetically altering two"cellular pathways"—biological signalling systems which cells use to communicate with each other.is commonly used in ageing research because it shares many genes with humans and only lives for between three and four weeks—so scientists can easily observe how various genetic or environmental factors affect lifespan.
Jarod Rollins of the MDI Biological Laboratory in Bar Harbor, Maine, is a lead author of a recent scientific paper that identifies synergistic cellular pathways for longevity that amplify lifespan fivefold in C. elegans, a nematode worm used as a model in aging research."The synergistic extension is really wild," Jared Rollins, co-lead author of the study from the Mount Desert Island Biological Laboratory in Maine, said in a statement.
"Despite the discovery in C. elegans of cellular pathways that govern ageing, it hasn't been clear how these pathways interact," Hermann Haller, president of the Mount Desert Island Biological Laboratory, said in a statement."By helping to characterize these interactions, our scientists are paving the way for much-needed therapies to increase healthy lifespan for a rapidly ageing population.
'Meanwhile, manipulating the IIS pathway leads to a 100 percent increase in lifespan.' 'The metabolism of ketones lowers the blood glucose and insulin thus decreasing the activity of the IIS and its attendant changes in the pathway described above' . .
Awesome! My roundworms were worrying me.
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