Regeneron to stop enrolling very sick COVID-19 patients in antibody trial

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Regeneron Pharmaceuticals said on Friday it would stop enrolling patients receiving advanced COVID-19 care in a trial testing its experimental antibody treatment in hospitalized patients, based on the recommendation of an independent safety board.

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The recommendation was based on a potential safety signal and an unfavorable risk-benefit profile at this time, the company said. Rival Eli Lilly & Co stopped enrolling such patients based on a similar suggestion earlier this week.

Both treatments belong to a class of drugs known as monoclonal antibodies. Regeneron’s drug, which was administered to U.S. President Donald Trump before he was hospitalized, was credited by him for his recovery from COVID-19. The treatment lowers virus loads in some non-hospitalized patients, the drugmaker said on Wednesday. The U.S. Food and Drug Administration is evaluating the treatment for a potential emergency use authorization in mild-to-moderate patients at high risk for poor outcome.

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