Regeneron antibody trial results translate into six fewer deaths for every 100 patients lacking natural antibodies, with investigators confident in therapy's benefit
The antibody therapy reduced the 28-day mortality of Covid-19 patients whose immune system did not mount an antibody response, shortened the hospital stay and reduced their chances of needing a ventilator.
Regeneron Pharmaceuticals Inc's Covid-19 antibody cocktail reduces deaths in hospitalised patients who have not mounted their own antibody response, a large British study published on Wednesday found.The therapy, REGEN-COV, has been granted emergency use authorisation for people with mild-to-moderate Covid-19 in the United States but results from the RECOVERY trial provide the clearest evidence of its effectiveness among hospitalised patients.
It found that the antibody therapy reduced by a fifth the 28-day mortality of people admitted to hospital with Covid-19 whose immune system had not mounted an antibody response, known as seronegative.The result translates into six fewer deaths for every 100 seronegative patients treated with the therapy, researchers said.
There was no discernible effect of the treatment on those who had generated natural antibody responses and were seropositive."People have been very, very sceptical, that any treatment against this particular virus would work by the time people get in hospital," Martin Landray, the joint chief investigator on the trial, told reporters. headtopics.com
"If you haven't raised antibodies of your own, you really would benefit from getting some," he said.The treatment also shortened the hospital stay of those who were seronegative and reduced their chances of needing a mechanical ventilator, Landray said.
Regeneron had previously said its treatment had shown enough promise in hospitalised patients to warrant continuing its trial. This data provides the first large-scale confirmation of that assertion.There were 9,785 patients hospitalised with Covid-19 who were randomly allocated to receive usual care plus the antibody combination therapy or just usual care, of which 30 percent were seronegative.
The RECOVERY trial also showed the steroid dexamethasone and Roche's arthritis drug Actemra (tocilizumab) cut deaths in hospitalised patients.While those treatments focus on inflammation caused by reaction to the coronavirus, Regeneron's therapy, which belongs to a class of biotech drugs called monoclonal antibodies, mimic natural antibodies the body produces to fight off the infection.
"This is the first time we've got one that's actually targeting the virus itself," Landray said, adding that it could be used along with the other treatments."It's not that you do one thing or another thing. These benefits are additive in these patients," he said. headtopics.com
Other similar treatmentsOther companies have been developing similar treatments.US emergency use authorization has been granted to antibody treatments developed by Eli Lilly and Co as well as by Vir Biotechnology Inc with GlaxoSmithKline Plc. Both are approved for use in mild-to-moderate cases.
On Tuesday, AstraZeneca said its antibody therapy had shown no evidence of protecting people from developing the disease following exposure, although other trials of its cocktail as a prevention or a treatment are ongoing.Landray said the RECOVERY results should give developers of other monoclonal antibody therapies optimism that they can also be used in some hospitalised patients.
"This opens up the possibility for many, many others," he said."People see a few negative trials and they say 'well that'll never work' and they opt out and go off and do something else. (But) this is very, very clear, the picture that we've got from this trial."Read more: TRT World »
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Regeneron Antibody Therapy Saves Lives Of Hospitalized Covid-19 Patients, Large U.K. Study FindsI am a London-based reporter for Forbes covering breaking news. Previously, I have worked as a reporter for a specialist legal publication covering big data and as a freelance journalist and policy analyst covering science, tech and health. I have a master’s degree in Biological Natural Sciences and a master’s degree in the History and Philosophy of Science from the University of Cambridge. Follow me on Twitter theroberthart or email me at rhartforbes.com Well The best decision I've made this year was investing in crypto and forex trading and earning from home, as professionals trade for me. With the help of pro_ElizabethD I've been earning great returns weekly, their is no way I’ll make loses!
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