Moderna begins next phase of Omicron-specific booster trial as study finds that antibodies remain durable despite 6-fold drop over 6 months

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Health, Moderna Vaccinates First Participant İn Phase 2 Trial Of Omicron-Specific Booster - Cnn

1/27/2022 1:25:00 AM

Moderna has announced that the first participant has been dosed in the company's Phase 2 clinical trial of a coronavirus vaccine booster shot that is specific to the Omicron variant

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Moderna is advancing the trial into its next phase as research published Wednesday in the New England Journal of Medicine found that a booster dose of the vaccine remained durable against the Omicron variant but did show signs of waning antibody protection."We are reassured by the antibody persistence against Omicron at six months after the currently authorized 50 μg booster of mRNA-1273. Nonetheless, given the long-term threat demonstrated by Omicron's immune escape, we are advancing our Omicron-specific variant vaccine booster candidate and we are pleased to begin this part of our Phase 2 study," CEO Stéphane Bancel said in a news release."We are also evaluating whether to include this Omicron-specific candidate in our multivalent booster program."Moderna said it expects to enroll about 600 people in the study, which will take place at up to 24 sites in the US. Some participants will have already received two doses of Moderna's vaccine, and some will have received a booster shot.Moderna promises to share its data from the trial with public health leaders so they can make evidence-based decisions on the best booster strategy against the coronavirus going forward.Covid pandemic 'nowhere near over,' WHO says Read MoreOmicron currently accounts for 99.9% of US Covid-19 infections, the US Centers for Disease Control and Prevention said Tuesday. The Delta variant makes up the remaining 0.1%.The new study says the Moderna Covid-19 booster shot remains durable against the Omicron variant, but the antibody protection wanes and is six times lower six months after getting boosted.The study also found that the neutralizing antibody levels declined against the Omicron variant much more rapidly than against the dominant strain of the virus that was circulating two years ago.Research teams from Moderna, Duke University, Emory University, the Fred Hutchinson Cancer Research Center, the Baylor College of Medicine, the University of Maryland School of Medicine and the National Institutes of Health looked at blood samples of people who had received Moderna's Covid-19 vaccine.Two doses of the vaccine elicited detectable neutralizing antibodies against the Omicron variant in 85% of the people one month after the second dose, but after seven months, neutralization of the variant was detected in only 55% of people.US pharmacies are rolling out free N95 masks as free Covid-19 tests begin to arrive in the mailGetting a third booster dose of 50 micrograms (μg) of vaccine resulted in a 20-fold rise in Omicron neutralization levels within four weeks after the boost was administered, but after six months, those levels fell 6.3-fold. By comparison, the durability of neutralization against the ancestral strain of the coronavirus fell only 2.3-fold after six months."While the antibody levels in study participants who received the boost continued to offer strong neutralizing activity, the levels of these antibodies declined faster for Omicron than for the early SARS-CoV-2 virus that was circulating two years ago," the researchers said in a news release.The study had a few limitations. It included a small sample size, so it may not completely reflect how well the vaccine neutralizes the virus in diverse populations or in varying lengths of time before a person gets a booster. These were also not real-life studies, and scientists looked only at antibodies generated in blood. Studies indicate that levels of antibodies correlate with real-world protection, however. Dave Montefiori, a co-author of the study and a professor in Duke University's Department of Surgery, said the drop in antibodies for the booster is very similar to the drop in antibodies to the Delta variant that was noted six months after the second dose of vaccine, which prompted the advent of booster doses.Boosters could make all the difference against Omicron"This is not uncommon, for mRNA vaccines or for vaccines in general," Montefiori said."Antibodies go down because the body figures it does not need to maintain them at that high level. It doesn't mean there is no protection. There is immunologic memory."Montefiori said that the concern is that the virus might change enough that the vaccine needs to be modified, and he noted Moderna's Omicron-specific booster trial.But for now, he said, the data is not there yet, and the vaccines"are still working, and the boost is helping it to work better, even against Omicron."Dr. William Schaffner, medical director of the National Foundation for Infectious Diseases and a professor of medicine at Vanderbilt University, was cautiously optimistic about the findings."The good news is that Moderna, when boosted, will give very high levels of antibodies, and of course, that's very encouraging," said Schaffner, who was not involved in the new study."But as we've learned with these Covid viruses, the antibody levels begin after a period of about six months to decline."Get CNN Health's weekly newsletter Sign up here to get The Results Are In with Dr. Sanjay Gupta every Tuesday from the CNN Health team.

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It’s BS Bro just admit you and big pharma have a thing going on it’s getting weird I WILL GLADY GET ANY VACCINE BIDEN TRUSTS FOR ME! Aujourd'hui, ce jour sera reconnu par le peuple du Canada comme le jour 1er jour de la liberté d'un mouvement mondial Today, this day will be recognized by the people of Canada as the day 1st day of freedom of a world movement

C Iiooooiiooon nnonnononononnopmmpojj Every one just got omnicron so we don't need it anymore

Moderna begins testing omicron-specific COVID-19 vaccine in adultsIt’s not clear whether global health authorities will order a change to the vaccine recipe in the wake of the hugely contagious omicron variant, since the original vaccines still offer good protection.

Covid is just a common cold CelerNetwork BluzelleHQ $iotx $Celer $blz 🚀🚀🚀 Just in time for Omnicron peak to pass Tired or these stories. The real virus is unending illegals. It is breaking Constitutional oaths. Insider trading by high up govt. officials. The real virus is soaring energy for homes,cars;food etc. It's 4 interest rate increases promised. Secret night flights dumping illegals.

THEFAKECOVIDVIRUS COVID Coronapositive COVID19 INJECTION CAUSES COMPLETE CIRCULATORY FAILURE IN 10MONTHS ANGIOPEPSINOGEN STEARATE STEROID HORMONE LEADS TO THE DIAN_CECHT REMEDY molnupiravir JIM MACNEILL THE ANTICHRIST IS THE ONE BEHIND ALL BAD THINGS SARAH TADEI IS HOST ... experts reveal, the secret ingredient is Robitussen and ginger ale

Baby world Sporti news Lebanon is dragging its time with the Middle East's unique bed soccer due to great fear and psychological pressure of South Korean football. Covid is not going away cos the lies aren't going away. Lies needs more lies to perpetuate itself Please help me! My name is Lin donglong, an employee of China telecom fuzhou branch. Company manager huang fei (communist party of China) organized the leadership of the gang of evil forces brutal persecution: surveillance location, insult,abuse, framed to take nude photos of me

Moderna starts clinical trial of booster shot targeting omicron Covid variantThe first participant in the trial has already received a dose of the omicron-specific booster shot, according to Moderna. What’s the point? Omicron gonna have run it’s course by the time it’s done… JAB ME HARDER DADDY. MORE!!!!!

a voice from Poland Auschwitz 27.01.1945 How many vaccine do you want people to take? It’s time to move on. This will never end. send me a dm World Cup 2022 Qatar Football Big Match South Korea VS Lebanon Coming soon Ugh omicron sucks Are vaxxes safe? Another shot for the most mild variant of them all? All about money and the sad part is people in this thread will actually inject this (fourth) shot Into them for no reason at all

Not again. They want us all to become ill. There is no need of having a vaccine against Omicron. The body itself must react on this. It's enough now. Pharma lobby is not to be supported, they don't care about health, money and power is their point.

Clinical Trials Begin For Pfizer And BioNTech’s Omicron-Specific Covid ShotI am a London-based reporter for Forbes covering breaking news. Previously, I have worked as a reporter for a specialist legal publication covering big data and as a freelance journalist and policy analyst covering science, tech and health. I have a master’s degree in Biological Natural Sciences and a master’s degree in the History and Philosophy of Science from the University of Cambridge. Follow me on Twitter theroberthart or email me at rhartforbes.com

The whole and complete cure is ivermectin, it won the Nobel Peace Prize in 2015... a miracle drug... stops all rna viruses..... look it up!! Nothing here to see В. ГАЙФУЛЛИН: О ЧЕМ МЕЧТАЕТ ПУТИН 'ВОВА ИДЁТ ПО ДОРОГЕ, А НА КОЛЕНЯХ БАБУШКА СТОИТ' ЭТИ ПОЙДУТ НА ВСЁ, ЧТОБЫ ОПРАВДАТЬ ВОРОВСТВО И СВОЁ СУЩЕСТВОВАНИЕ. В РОССИИ 'НИЧЕГО НЕ ТРЕВОЖИТ' ПУТИНА ГДЕ СМЕРТНОСТЬ ПРЕВЫШАЕТ РОЖДАЕМОСТЬ-ЭТО ФАШИЗМ

Last month the “booster” was one that sealed the deal. So how many boosters are people going to be required to get, is it every variant or twice a year. Once every year? Enough. I believe that without Covid-19, American pharmaceutical companies have started to develop vaccines. If you want to turn vaccines into money, you can only spread viruses.

Sign me up because yes I'm a sheep that wants to be a guinea pig. Seriously, I am just taunting anti vaxxer morons with that first part. I am willing to be a test subject. I don't have dependents, I will take the risk. There is no way people are actually getting this are they The word vaccine needs to be completely removed from the title. Call it what it is…. A booster, that’s it. Yes I’m vaccinated lol.

Baby world emergency science big news Dr. Natasha Waist Walker of the International Radio Astronomy Research Center at Curtin University in Australia said she is confident that aliens have sent powerful radio waves from Earth. For God's sake get the vaccine or feel the wrath of Delta & Omicron'. From the cover version of the Beatles song Helter Skelter, vaccines VaccinesSaveLives BoosterJab Booster Omicron COVIDIOT Deltacron OmicronVariant GetVaccinated BoosterDose

Pfizer Begins Clinical Trial for Omicron-Specific COVID VaccinePfizer has begun a study comparing its original COVID-19 vaccine with doses specially tweaked to match the omicron variant 𝖨𝗍'𝗌 𝗈𝗏𝖾𝗋 6𝗆𝗈𝗇𝗍𝗁𝗌 𝗇𝗈𝗐, 𝗂'𝗆 𝗌𝗍𝗂𝗅𝗅 𝗆𝖺𝗄𝗂𝗇𝗀 𝗀𝗈𝗈𝖽 𝗆𝗈𝗇𝖾𝗒 trading crypto 𝗐𝗂𝗍𝗁 𝗍𝗁𝖾 𝗁𝖾𝗅𝗉 𝗈𝖿 stephinieweller 𝖼𝗈𝗇𝗍𝖺𝖼𝗍 her now and enjoy crypto trading with good profits, stephinieweller

Hi, check out my page. Hi. Check out my page. After 10 booster shots on my Moderna loyalty card do I receive a free pizza? Me taking my kid to get their 100th Covid vaccine. Too late I refuse all this crap. Doesn’t matter if you are vaccinated or not you can get Covid 19!! End of story, and as far as it being worse If you are not vaccinated that is not proven at all!!

What a joke If everyone just got the first 2 jabs we wouldn’t need all these booster jabs. Who’s fault is that? The world didn't have this problem until airlines had huge fleets of jumbo jets making transoceanic travel easier, faster, and more affordable. The more mobile we got, the more easily these viruses have been able to spread. Now, more efficiently than at any time in human history.

Nope....I think we are good off all these vaccines that keep coming and not working for this or that.....sounds like we're test dummies and your trying your next attempt again.......no thank you.

Clinical Trials Begin For Pfizer And BioNTech’s Omicron-Specific Covid ShotI am a London-based reporter for Forbes covering breaking news. Previously, I have worked as a reporter for a specialist legal publication covering big data and as a freelance journalist and policy analyst covering science, tech and health. I have a master’s degree in Biological Natural Sciences and a master’s degree in the History and Philosophy of Science from the University of Cambridge. Follow me on Twitter theroberthart or email me at rhartforbes.com For every variant u must take a shot 😅🤣😂😹

Clinical Trials Begin For Pfizer And BioNTech’s Omicron-Specific Covid ShotI am a London-based reporter for Forbes covering breaking news. Previously, I have worked as a reporter for a specialist legal publication covering big data and as a freelance journalist and policy analyst covering science, tech and health. I have a master’s degree in Biological Natural Sciences and a master’s degree in the History and Philosophy of Science from the University of Cambridge. Follow me on Twitter theroberthart or email me at rhartforbes.com

(CNN)Moderna announced Wednesday that the first participant has been dosed in the company's Phase 2 clinical trial of a coronavirus vaccine booster shot that is specific to the Omicron variant. Moderna is advancing the trial into its next phase as research published Wednesday in the New England Journal of Medicine found that a booster dose of the vaccine remained durable against the Omicron variant but did show signs of waning antibody protection."We are reassured by the antibody persistence against Omicron at six months after the currently authorized 50 μg booster of mRNA-1273. Nonetheless, given the long-term threat demonstrated by Omicron's immune escape, we are advancing our Omicron-specific variant vaccine booster candidate and we are pleased to begin this part of our Phase 2 study," CEO Stéphane Bancel said in a news release."We are also evaluating whether to include this Omicron-specific candidate in our multivalent booster program."Moderna said it expects to enroll about 600 people in the study, which will take place at up to 24 sites in the US. Some participants will have already received two doses of Moderna's vaccine, and some will have received a booster shot.Moderna promises to share its data from the trial with public health leaders so they can make evidence-based decisions on the best booster strategy against the coronavirus going forward.Covid pandemic 'nowhere near over,' WHO says Read MoreOmicron currently accounts for 99.9% of US Covid-19 infections, the US Centers for Disease Control and Prevention said Tuesday. The Delta variant makes up the remaining 0.1%.The new study says the Moderna Covid-19 booster shot remains durable against the Omicron variant, but the antibody protection wanes and is six times lower six months after getting boosted.The study also found that the neutralizing antibody levels declined against the Omicron variant much more rapidly than against the dominant strain of the virus that was circulating two years ago.Research teams from Moderna, Duke University, Emory University, the Fred Hutchinson Cancer Research Center, the Baylor College of Medicine, the University of Maryland School of Medicine and the National Institutes of Health looked at blood samples of people who had received Moderna's Covid-19 vaccine.Two doses of the vaccine elicited detectable neutralizing antibodies against the Omicron variant in 85% of the people one month after the second dose, but after seven months, neutralization of the variant was detected in only 55% of people.US pharmacies are rolling out free N95 masks as free Covid-19 tests begin to arrive in the mailGetting a third booster dose of 50 micrograms (μg) of vaccine resulted in a 20-fold rise in Omicron neutralization levels within four weeks after the boost was administered, but after six months, those levels fell 6.3-fold. By comparison, the durability of neutralization against the ancestral strain of the coronavirus fell only 2.3-fold after six months."While the antibody levels in study participants who received the boost continued to offer strong neutralizing activity, the levels of these antibodies declined faster for Omicron than for the early SARS-CoV-2 virus that was circulating two years ago," the researchers said in a news release.The study had a few limitations. It included a small sample size, so it may not completely reflect how well the vaccine neutralizes the virus in diverse populations or in varying lengths of time before a person gets a booster. These were also not real-life studies, and scientists looked only at antibodies generated in blood. Studies indicate that levels of antibodies correlate with real-world protection, however. Dave Montefiori, a co-author of the study and a professor in Duke University's Department of Surgery, said the drop in antibodies for the booster is very similar to the drop in antibodies to the Delta variant that was noted six months after the second dose of vaccine, which prompted the advent of booster doses.Boosters could make all the difference against Omicron"This is not uncommon, for mRNA vaccines or for vaccines in general," Montefiori said."Antibodies go down because the body figures it does not need to maintain them at that high level. It doesn't mean there is no protection. There is immunologic memory."Montefiori said that the concern is that the virus might change enough that the vaccine needs to be modified, and he noted Moderna's Omicron-specific booster trial.But for now, he said, the data is not there yet, and the vaccines"are still working, and the boost is helping it to work better, even against Omicron."Dr. William Schaffner, medical director of the National Foundation for Infectious Diseases and a professor of medicine at Vanderbilt University, was cautiously optimistic about the findings."The good news is that Moderna, when boosted, will give very high levels of antibodies, and of course, that's very encouraging," said Schaffner, who was not involved in the new study."But as we've learned with these Covid viruses, the antibody levels begin after a period of about six months to decline."Get CNN Health's weekly newsletter Sign up here to get The Results Are In with Dr. Sanjay Gupta every Tuesday from the CNN Health team. We've seen it before, Schaffner said, but we don't exactly know how this translates into real-world performance."It's not clear whether this translates into reduced protection particularly for severe disease," he said.Large population data shows that two doses of the vaccine plus a booster provides rigorous protection against severe disease, even against the Omicron variant."I think this study reinforces that basically, what was seen with the Pfizer vaccine plus boosting is replicated with Moderna also, and it may also be a harbinger or an early sign that at some interval down the road, as we get over this pandemic and get to a truce with this virus, that we may well have to get a periodic booster in order to maintain protection."