In Honor of Grey's Anatomy's 15th Anniversary, Photos of the Original Cast Then & Now

Izzie Stevens started the series as the intern who grew up in a trailer park with her mother, and paid her way through medical school by modeling. She was kind and trusting and loved to bake, which made her the perfect antithesis for the dark and twisty Meredith and Cristina. It was a rough ride for Izzie who, in season two, fell in love with a patient, Denny Duquette, who needed a heart transplant, risked her career to get him one, and then had to cope with his death.

While viewers didn’t get to see her again, she was mentioned as the reason Karev left the hospital in the show’s 16th season to be with her and their twins. It all started when Heigl withdrew her name from Emmy nominations in 2008, which didn’t exactly keep her in good graces with the show’s creator and producers.

In 2010, Shonda Rhimes told Oprah Winfrey of Heigl’s move, “On some level, it stung and on some level I was not surprised. When people show you who they are, believe them.” Heigl told Howard Stern that she did apologize to Rhimes, saying, “I went in to Shonda and said, ‘I’m so sorry. That wasn’t cool, and I should not have said that.’ And I shouldn’t have said anything publicly. But at the time, I didn’t think anyone would notice … I just quietly didn’t submit and then it became a story, and I felt I was obligated to make my statement, and … ‘Shut up, Katie.’”

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