These results showed"no material differences in any of the microvascular complications evaluated," the authors write. But for the endpoint of any cardiovascular disease, liraglutide significantly outperformed the other three agents, reducing the relative hazard ratio by 29%."With many treatment options available for type 2 diabetes, healthcare providers and patients can find it difficult to know which drug is best for which person," commented Griffin P.
in enrolled patients. They also note the study design did not take into account"the concept of subtypes of type 2 diabetes" that could affect differential risks for cardiovascular and microvascular outcomes. But Rydén and Standl blunt this apparent endorsement of liraglutide and the pricey GLP-1 agonists based on the GRADE findings with a caveat.
"GRADE effectively shows which drugs worked best at achieving and maintaining blood glucose targets over time, but we need to establish even more effective strategies for the long-term maintenance of acceptable glucose levels," summed up Nathan in a written statement.
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