Doctors Successfully Transplanted A Gene-Edited Pig Kidney – And They Have Plans To Scale Up

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The successful transplantation by scientists at University of Alabama-Birmingham paves the way to clinical trials — and hope for thousands of patients suffering kidney disease

are currently on the waitlist to receive a kidney donation, according to the Health Resources and Services Administration, but only around 20,000 kidney donations are performed each year. Patients have to wait on average nearly 4 years to get a kidney, and in the meantime have to suffer from kidney disease and renal failure. Hundreds of others die before a transplant is made available.

The kidneys used in this transplant came from a genetically modified pig developed by Revivicor, a subsidiary of United Therapeutics. This particular line of pigs has 10 key gene edits that are designed to both prevent a human immune system from rejecting the organ, as well as a key edit that constrains the size of the pig kidney to better match a human kidney. The pigs themselves were raised in a pathogen-free facility.

Prior to the surgery, a crossmatch compatibility test between the pig kidney and patient was performed to ensure a good tissue match. Once the match was determined, the kidneys were removed from the donor pig and processed for transplantation in a manner similar to human kidneys.

 

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