The Omicron variant may have originated in mice before jumping to humans, according to some scientists.
K417 and E484 make it easier for Omicron to escape antibody protection, while N501 is linked to increased infectivity. Mutations Q493 and Q498 indicate that it is better suited to infect mice. “We believe that the coronavirus slowly accumulated mutations over time in mice, before it was transmitted back to humans by reverse zoonotic.”
– the part of mouse cells that the virus would typically use to gain entry has little affinity for the standard SARS-CoV-2 spike protein. Scientists in general have been skeptical of the animal origin story of Omicron, although most believe it’s too early to understand the origins of the variant.
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