De novo mutations identified by whole-genome sequencing implicate chromatin modifications in obsessive-compulsive disorder

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While scientists have suggested that OCD likely has a substantial genetic basis, a new study in ScienceAdvances finds rare genetic mutations that appear in individuals but not in their parents may be a significant risk factor for the disorder.

J. F. McRae, S. Clayton, T. W. Fitzgerald, J. Kaplanis, E. Prigmore, D. Rajan, A. Sifrim, S. Aitken, N. Akawi, M. Alvi, K. Ambridge, D. M. Barrett, T. Bayzetinova, P. Jones, W. D. Jones, D. King, N. Krishnappa, L. E. Mason, T. Singh, A. R. Tivey, M. Ahmed, U. Anjum, H. Archer, R. Armstrong, J. Awada, M. Balasubramanian, S. Banka, D. Baralle, A. Barnicoat, P. Batstone, D. Baty, C. Bennett, J. Berg, B. Bernhard, A. P. Bevan, M. Bitner-Glindzicz, E. Blair, M. Blyth, D. Bohanna, L. Bourdon, D.

Lim, C. Longman, G. Lowther, S. A. Lynch, A. Magee, E. Maher, A. Male, S. Mansour, K. Marks, K. Martin, U. Maye, E. McCann, V. McConnell, M. McEntagart, R. McGowan, K. McKay, S. McKee, D. J. McMullan, S. McNerlan, C. McWilliam, S. Mehta, K. Metcalfe, A. Middleton, Z. Miedzybrodzka, E. Miles, S. Mohammed, T. Montgomery, D. Moore, S. Morgan, J. Morton, H. Mugalaasi, V. Murday, H. Murphy, S. Naik, A. Nemeth, L. Nevitt, R. Newbury-Ecob, A. Norman, R. O’Shea, C. Ogilvie, K. R. Ong, S. M. Park, M. J.

 

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ScienceAdvances So very interesting.🙏

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