Coronavirus Today: Why booster shots are so complicated

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Why were decisions about COVID-19 booster shots so fraught? Blame the data.

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an FDA advisory panel pushed back. Instead, the panel voted to endorse emergency-use authorization of boosters only for specific, higher-risk groups.

How did something that seemed like a no-brainer get so complicated? You can blame the data on vaccine effectiveness, which show that,Doses of Pfizer’s COVID-19 vaccine are prepared for a clinic in Washington, D.C.One slide the CDC advisors examined this week showed how effective the Pfizer and Moderna vaccines have been at preventing people from being hospitalized with COVID-19. The results were broken down into two periods: from January to May and from June to August..

Likewise, in those ages 50 to 64, the Pfizer vaccine’s effectiveness at preventing COVID-19 hospitalizations dropped from 93% in the first five months to 84% in the next three months. That difference, however, wasn’t large enough to rule out a statistical fluke.Those ages 30 to 49 had the same level of vaccine effectiveness in both periods: 82%. And for those 18 to 39, the vaccine’s effectiveness seemed to increase, from 82% to 85% (though that could have been a statistical fluke as well).

in effectiveness at preventing COVID-19 hospitalizations. For those 65 and older, it went from 91% in the first five months to 86% in the next three months; for those 50 to 64, it dipped from 93% to 91%; for those 30 to 49, it rose from 85% to 99%; and for those 18 to 29, it dropped from 91% to 82%. None of those changes were statistically significant.

Walensky agreed that the booster data currently available “are not perfect.” But she said they’re good enough “to make a decision about the next stage in this pandemic.” When the CDC and FDA get better information on how the vaccines are holding up,There was one thing everyone agreed on: The most important goal remains getting first doses into the arms of those who haven’t received any vaccine at all.said Dr. Helen Keipp Talbot of Vanderbilt University.

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