Health, Longevity, Blood, Plasma, Silicon Valley, Aging, Anti-Aging, Alkahest

Health, Longevity

Can blood from young people slow aging? Silicon Valley has bet billions it will

Biotech startups are trying to hack the process of aging and, in the process, stave off the most devastating diseases

4/7/2021 6:20:00 PM

Can blood from young people slow aging? Silicon Valley has bet billions it will. Biotech startups are trying to hack the process of aging and, in the process, stave off the most devastating diseases.

Biotech startups are trying to hack the process of aging and, in the process, stave off the most devastating diseases

Courtesy of NIH/National Institute on AgingThe result is a flood of investment money, an explosion of research into what precisely goes wrong in our bodies as we get old and the promise of clinical results down the road.In the months before the pandemic, investors ponied up billions of dollars to fund biotechs aimed at commercializing the new science. Some biotech firms are developing drugs and infusions designed to clean up zombie-like cells and metabolic junk that accumulate with age. Others hope to infuse new vigor into flagging cellular components, such as stem cells, or spur the body into beneficial actions by adding obscure hormones or proteins, that decrease as we get older. The NIA, under its director, Richard Hodes, recently announced plans to spend about $100 million over the next five years on basic research aimed at understanding"cellular senescence."

"You have no idea how many people are interested to investing money in longevity," said Nir Barzilai, the founding director of the Institute for Aging Research at Albert Einstein College of Medicine of Yeshiva University, and the founder of a company aimed at mitochondrial health."There are billions of dollars."

Although the vast majority of these efforts remain in preclinical development, several have recently enteredFDAtrials and could potentially hit the market in a few years. Some are already appearing on the gray market, raising concerns that hucksters are peddling anti-aging snake oil. Others, meanwhile, worry what might happen if these drugs actually do deliver on their promise: Will poor young people be coerced into selling their blood to elderly billionaires? Will magical anti-aging pills become the province of the Park Avenue and Hollywood rich, like facelifts, hair plugs and botox injections? Will the rest of us senile peasants be forced to watch them age backwards as we are left to wither and die?

Hacking Old AgeGetting old usually doesn't end well. Despite massive gains in human life expectancy—over the last 150 years, it has almost doubled in many developed nations, though it dipped in the past year due to the pandemic—we still haven't found a way to halt the relentless toll time takes on our bodies.

Older people practicing yoga at an assisted living facility to help stay limber; Silicon Valley is working on its own solution to the mobility issues and other problems of older age.Craig F. Walker/The Boston Globe/GettyWhen we grow old, our immune systems begin to break down, creating a state of low-level inflammation that suppresses cellular regeneration and leads to those aches and pains. We may be living longer, but we are hurting. As our mitochondria cease to effectively produce energy for our cells, we spend many of those hard-won extra years taking afternoon naps. As our stem cells grow lethargic and quiescent, our muscle mass shrinks and our bones become increasingly fragile. In short, our bodies fall apart.

The first hint that hacking the biology of aging might be possible came, improbably enough, from a series of laboratory experiments on a lowly species of roundworm. In the late 1980s and early 1990s, studies of identical twins had already shown that about 30 percent of longevity in humans could be attributed to genetics. But most scientists believed the process of aging was far too complex a phenomenon to modulate simply by tweaking a couple genes or taking a pill.

Then in 1993, Cynthia Kenyon, a biologist at theUniversity of Californiain San Francisco, doubled the lifespan of a worm from three weeks to six by mutating a single gene. The work suggested the possibility of drugs that could increase longevity without targeting specific diseases. It suggested that the process of aging itself might be manipulated.

At the time, a fringe group of longevity enthusiasts were, unknowingly, already trying to do what Kenyon did in roundworms through the practice of calorie restriction. This idea took off when gerontologist Roy Walford of UC Los Angeles doubled the lifespan of lab mice by restricting their caloric intake and then became a vocal advocate for the practice in humans. He penned a series of best-selling books in the 1980s and adopted a 1,600-calorie-a-day diet for the last 30 years of his life. Today, his emaciated acolytes can still be spotted at longevity conferences, meticulously measuring out their food during lunch breaks.

Emerging science now explains why there may be something to this method of bio-hacking. In humans, insulin is the hormonal signal that cues our cells to absorb sugar and convert it to energy. Along with a closely related hormone called Insulin like-Growth Factor 1 (IGF1), insulin affects a large number of other cellular processes, including the rate of cellular division, which many believe is directly related to aging. When the insulin and IGF1 in humans or analogous compounds in worms are dialed down—because we are starving, or the genes have been tweaked—a host of cellular repair mechanisms that are normally on standby kick into high-gear.

The adaptation makes sense from the perspective of evolution. Prehistoric times consisted of long periods of scarcity punctuated by precious windows of abundance. Since there was no telling how long the good times would last, our ancestors evolved the ability to grow and build fat and muscle as quickly as possible. A feast triggered the body to release insulin and IGF1, which allowed our cells to begin absorbing glucose and spurred them to pour energy into cellular reproduction and regeneration for as long as our insulin levels remain high.

Beta-amyloid plaques and tau in the brain.Courtesy of NIH/National Institute on AgingWhen calories were no longer easy to come by, our bodies adjusted by lowering insulin and IGF1 levels—a cue for our cells to slow regeneration and reproduction, and instead divert energy into cellular processes most likely to facilitate our survival through cold, lean times. The human body protects cells it already has: it produces more enzymes to ensure proteins don't misfold, it ramps up the machinery designed to repair broken DNA and it breaks down cellular debris and defective cells it might otherwise ignore, scavenging for parts it can use to feed its healthier cells through the lean days. In the process, it cleans up cellular garbage that, particularly as we grow older, likely promotes low-level inflammation.

Currently there is no FDA-approved indication for drugs that target the process of aging itself. To win approval, drugs must target a specific disease. It's no coincidence that some gerontologists have chosen the popular diabetes drug metformin to serve as the"template" for a new class of FDA-approved anti-aging drugs. It works by influencing the body's sensitivity to insulin and can have an effect on the pace of metabolism and energy expenditure. If studies now underway confirm its efficacy and it wins approval, it would create an entirely new regulatory category of drugs that, rather than treating specific diseases, will work to prevent our bodies from deteriorating further once we have already developed one.

"Aging drives disease," says Albert Einstein's Barzilai, who is leading the study."That's our point. If we stop aging, it stops driving the diseases."A whole host of other potential anti-aging-drugs might not be far behind. Molecular biologists discovered a second important way to manipulate the aging process in the early 2000s by breeding strains of baker's yeast, fruit flies and worms to live longer. They sequenced the genomes of the hardiest strains and then worked backward to identify the specific genetic variants that seemed be associated with increased longevity. That led them to mTOR, a genetic variant that serves as the target of an anti-aging drug called rapamycin, which is now undergoing clinical trials. Among these scientific efforts is a massive longitudinal study of canine aging at the University of Washington, which has enrolled 30,000 dogs and plans to select 500 lucky pooches to participate in a rapamycin trial.

COVID-19 Could Increase Dementia, Other Brain Disorders for Decades to ComeRead moreCOVID-19 Could Increase Dementia, Other Brain Disorders for Decades to ComeThe hunt for other"control knobs" that might be targeted with drugs continues at research institutions around the world. A third approach would increase the production an enzyme called AMP-Kinase, which modulates cellular processes like growth and metabolism, based on the level of energy available for consumption. It, too, has emerged in recent years as another promising target, along with many other molecules, hormones and proteins that appear to decline with age and that play a key role in cellular repair, regeneration, protection and efficient function.

Vera Gorbunova, co-director of the Rochester Aging Research Center at the University of Rochester, and her colleagues compared 18 rodent species, including, beavers, hamsters and mice, sorted them by longevity, and looked for interesting patterns. Significantly, they found that"more robust" repair of broken DNA, the molecular-level cellular blueprints found in every one of our cells, seems to coevolve with longevity. In other words, species that live longer have a more robust ability to fix the kind of problems that inevitably occur with age. The research was recently published in the journal Cell.

Vera Gorbunova, co-director of the Rochester Aging Research Center at the University of RochesterUniversity of Rochester"There was a very strong correlation to how long different species live and how well they repaired DNA breaks," Gorbunova said."We also look at why it's better. We found a protein that is very important in DNA repair and it is more active in long-lived species."

Gorbunova has done some of her most exciting work on an obscure superstar in the longevity field known as the naked mole rat, a furless, wrinkled rodent with a pair of beaver-like incisors that lives in tunnels in East Africa. The rat, sometimes referred to by its cuddly nickname,"Sand Puppy," has an unusually long-life expectancy—30 years, 10 times longer than its close cousin, the North American field mouse, which rarely makes it past three.

Gorbunova traces much of the hardiness of the mole rats to an abundance of hyaluronic acid, a major component of skin that is involved in tissue regeneration. Although mice and humans also have hyaluronic acid, the tissues of naked mole rats are"saturated with it," says Gorbunova. In addition to having strong antioxidant properties, and others that seem to attenuate the destructive consequences of the chronic, widespread inflammation that often accumulates with age, the abundance of hyaluronan also seems to prevent the growth of malignant cancer cells.

"Hyaluronan is a very nice story because we can see the possibility of translating it to humans," Gorbunova says."We have it, but we don't have a lot of it, so I think there is room for improvement. We can find ways to increase our own levels of hyaluronan."

To Gorbunova, the differences between the mouse and naked mole rat are easily explained by evolution—their respective adaptations are geared toward increasing their chances of reproductive success."For a mouse, the best strategy to have more progeny is to be very, very prolific very quickly because then somebody's going to eat it, and it just doesn't have a chance to live longer," she explains."The naked mole rat lives underground and has very few predators. And they breed until very late in life. So they would evolve the mechanism to allow them to live longer and to breathe as long as possible just because they can. No one is there to eat them. And the longer they live the more progeny they have."

A naked mole rat is pictured at the University of Rochester January 31, 2018.J. Adam Fenster/University of RochesterThe same logic applies to humans—and it also explains why our bodies fall apart. Diseases of aging, many gerontologists now argue, are the natural consequence of the advances in modern lifespan, which now extends decades past reproductive age, and thus has not been subject to the same exquisitely efficient evolutionary sculpting that might increase our odds of surviving them."If you put this work in an evolutionary perspective, we were not supposed to live that long," says Gerard Karsenty, who chairs the Department of Genetics and Development at Columbia University Medical Center."Aging is an invention of mankind. No animal species has successfully cheated its own body—cheated nature—except mankind. Elephants may live for 100 years but they lived for 100 years a million years ago. Humans have outsmarted their own body."

But what does any of this have to do with Wyss-Coray and Villeda's young blood?RegenerationSaul Villeda now runs a lab at UCSF on a hill that Over-looks San Francisco's famed Haight-Ashbury. Winding stairs lead to a fluorescent-lit basement hallway and a cramped suite of rooms stacked wall-to-wall with mouse cages. There is something unusual about many of the mice in the room. They are ambulating through their cages, with two heads, two sets of legs and double-wide bodies.

The doublewide mice are products of a macabre procedure known as"parabiosis," a technique Villeda mastered as a graduate student in the lab of Wyss-Coray for the improbable experiment that led to the founding of Alkahest and the clinical blood trials aimed at treating aging. The procedure, pioneered in the 19th century by the French scientist Paul Bert, merges the circulatory systems of two rodents by cutting open their bodies and sewing their wounds together, so that their bodies fuse as they heal.

To learn it, Villeda had an expert teacher: Thomas Rando, a neurologist who studies longevity and occupies the office next door to Wyss-Coray. Rando first got the idea to revive the obscure technique back in the early 2000s. He had come to believe that one of the reasons our bodies lose their regenerative powers as we grow older is because our stem cells stop receiving the molecular-level signals needed to activate them. Rando did not know what those signals might be. But he knew where to find them—the blood of younger mice. Enter parabiosis.

To test out his hypothesis, Rando conjoined elderly mice with younger rodents so that they shared the same circulatory system, then tested their ability to heal small wounds. The results were dramatic. Elderly mice were able to repair small tears in their muscles far faster than their peers not conjoined to younger mice. The younger mice, on the other hand, healed far slower than they normally would.

The results were exhilarating. They suggested that stem cells could be revitalized simply by reintroducing back into the blood stream the molecules, present in young blood, that could turn them on. The next step was finding the specific youth-promoting factors in the blood responsible for the change. But that would not be easy.

"It's as big a fishing expedition as you can possibly imagine," Rando warned at the time, noting the thousands of proteins, lipids, sugars and other small molecules in the blood serum.Woman, 73, Who Should've Gotten Alzheimer's, Didn't—Renewing Hope for Cure

Read moreWoman, 73, Who Should've Gotten Alzheimer's, Didn't—Renewing Hope for CureWatching this unfold from next door, Wyss-Coray, who studied Alzheimer's Disease, and then-graduate student Villeda were dubious that they could induce a similar rejuvenation in the brain. Whatever it was in the young blood that spurred the regeneration, it seemed unlikely it would be able to pass the blood-brain barrier, the semipermeable border that keeps circulating blood, and much of the cargo it carries, from entering the central nervous system."But we did it anyways, because I was a graduate student at the time, and Tony will always support crazy ideas," Villeda recalls.

After conjoining elderly and young mice, Villeda sacrificed the elderly mice, cut their brains into tiny slices, and stained them with a special dye that bound to baby neurons. Then he counted up the number of new neurons and compared them to normal levels of neuronal growth in similarly aged mice. The results, when he published them in 2014, shocked the scientific world. The infusion of new blood led to a threefold increase in the number of new nerve cells generated in the brains of the elderly mice. But that was not the only revelation. He had already shown that the young members of the conjoined old-young mouse pairs generated far fewer new nerve cells than young mice left to roam free, untethered to their elderly cousins. And while the old mice grew more energetic, the younger mice suddenly behaved as if they were middle-aged.

Since parabiosis is not an option for human patients, Villeda and Wyss-Coray tried to pull off the same trick with a simple infusion of blood plasma. There, too, the results were better than they expected. On spatial-navigation tasks, such as finding an underwater platform to rest on in a water-filled chamber, the young mice that had received injections of"old blood" performed far worse than a group that got injections of plasma from younger mice. Once infused with the blood of young mice, the old-blood mice, meanwhile, were able to locate the platform as easily as their younger brethren.

A healthcare worker holding convalescent plasma.Ichal Chem/Riau Images/Barcroft Media/GettyThe results generated worldwide headlines. And soon Wyss-Coray and his protégé Villeda began receiving many bizarre and at times macabre emails. One chilling missive came from a man who offered to provide all the blood Wyss-Coray might need for such an experiment—he claimed he could obtain it from human children of any age. There was also a flood of heartfelt pleas from Alzheimer's patients and their loved ones inquiring about human trials, desperate to stave off the ruthless march of the incurable, degenerative disease.

The query that changed Wyss-Coray's life came from the family of recently deceased Chinese billionaire Chen Din-hwa, also known as Hong Kong's"King of Cotton Yarn," for the yarn-supply business he established in 1949.On his death bed, suffering from advanced Alzheimer's disease, Din-hwa, 89, received blood plasma infusions for an unrelated medical condition. In the hours that followed, his grandson Vincent would later tell Wyss-Coray, the old man grew surprisingly alert and coherent, allowing his loved ones a few precious final moments of connection. The young blood seemed to have had a remarkably restorative effect on the old man, just as it had for Wyss-Coray's mice.

After Din-hwa's death in 2012, Vincent, a molecular biologist from UC Berkeley, tried to explain the bizarre phenomenon. He eventually found Wyss-Coray and Villeda's first paper on the mice.The word got to Wyss-Coray via a mutual acquaintance in the biotech industry."He said, 'Tony, there's this rich person in Hong Kong'," Wyss-Coray recalls."'He wants to start a company. Are you interested?'"

Vincent and Wyss-Coray formed Alkahest, a San Carlos-based biotech that has raised upward of $150 million from the Din-hwa family company—the Nan-Fung Group—Stanford University, the Michael J.Foxfoundation and Grifols, the mammoth Spanish Blood Plasma company that would eventually buy everyone else out.

The real work of finding out precisely what it was in the blood that caused this remarkable transformation was only just beginning.Aging ChemistryIn the years since the initial mice experiments, Villeda, Wyss-Coray and a number of independent investigators have identified an array of proteins that seem to have promising restorative effects—or, in the blood of elderly mice, detrimental effects. Both kinds could prove useful as potential drug targets. If DNA is the body's blueprint, proteins are its building materials. These essential molecules, composed of amino acids, are not only the fundamental material from which we construct bone, skin, muscle and brain cells. They are also the units used to make hormones and other molecular-level signaling agents that carry messages from one part of the body to another. With age, it seems, many of the proteins we need to function efficiently decline, while proteins that aren't good for us accumulate in inconvenient places and gum up the works.

Villeda has isolated a molecule present in mice that blocks the regeneration of brain cells and promotes cognitive decline. The molecule seems to be connected to the gradual, age-related breakdown of the immune system, and when injected into the blood of younger mice, these proinflammatory molecules can impair cognition. And in May 2019, Wyss-Coray demonstrated it was possible to block the activity of another protein that accumulates with age, triggering a powerful restorative effect and vastly improving the performance of elderly mice on tests that measure memory and cognitive abilities.

Read more: Newsweek »

What's Up: April 2021 Skywatching Tips from NASA

What are some skywatching highlights in April 2021? Look for the rosy arch known as the Belt of Venus at sunset, then find the constellation Leo overhead on ...

shoe0nhead JohnRentoul one for you here. ADREN0CHROME!!! DomDasThreads chega aqui rapidinho u ppl are SICK Water filter salesman was right. 😟 Quem acompanha o DomDasThreads já sabe do que eles são capazes. *QAnon has entered the chat* Vampirism in science. Literally no difference between this and cannibalism.

This tells a similar story if you pay attention I did nazi this coming. there are ways to bring youth to the aging without using the blood of children sunshine exercise diet spirituality optimism joy Hey, I've seen this movie. The ending was lame. Hot take... stop this not content with metaphorical blood sucking, boomers are moving on to literally sucking our blood now

Apologise to the man We know, that “nut job, conspiracy theorist” Alex Jones already told us.. Apologize just ask what Hillary thinks Dalas no mires Little late. Alex Jones said that on Joe Rogan years ago. I hate the antichrist 'Startups', who they kidding? 'Oh no it is just a onspiracy theory' Lol ppl have been talking about this for years

Every day Alex Jones is proved right more and more. joshparmour referring to our brief conversation yesterday lol this is maddeningly creepy stellarposts think I brought this up yesterday hahah, y’all thought I was nootz Isn't this what Alex Jones used to say? datmanhollon DrewStubbmuffin I need some blood here💉🩸

Silicon Valley says it and everyone believes it. Alex Jones says it, and gets banned from all social media. Schizophrenic ideas Imagine your grandmother at like 80 yet she looks fucking 20 like that would make things super awkward Alex Jones was right. Yikes. benaveryisgood JamieVernon You're gonna get your turn. Devil gonna watch you burn.

BryceWeiner wait what? This is evil. Disgusting. VAMPIRES ARE REAL!!! OMG ALEX JONES WAS RIGHT Oh sure but when I try to get the blood of the elderly it’s “weird” Well, having kids is officially off the table 🤣 TimJDillon I fucking knew they were stealing blood for this shit, no one believed. Never give blood.

One out of one people die... Then comes the judgment! Comment faire passer l'adenochrone comme le traitement miracle, ainsi perduré l'enlèvement, la torture, le massacre des enfants ! Tout ça dans l'ignorance la plus totale ! Stuff like this makes me wonder why the libertarian left and right fight with each other. Crazy elites could keep guillotines and wood chippers busy for years.

Goddamn Alex Jones knew it. Come on Newsweek, now you have done it. Got them Q Quacks all fired up again, here comes the flood of baby sacrifices and blood rings. I thought we were finally going to get a break. Okay As long as we're thinking outside the box, may I suggest: Toynbee idea in movie 2001 resurrect dead on planet Jupiter

Vampires. Literally. NickLutsko already confirmed this. Oh no They want to ease out ever so slightly what the Qanon cooks were all saying this whole time. Makes a mf think Child trafficking is real. It's time to intensify investigations. Lol 😂 the length of your telomeres are what determine how rapidly you age.

ItsDaue RyanStephanik I swear this was part of the plot in The 100 right? NEED MOAR BLOOD Im tired of being right! Liz Love! Literally all of hollywood is addicted to baby blood, it’s no damn secret unless you just don’t believe it ... Fuck it mask off. so Alex Jones was right once again Paul Rudd just turned 52 and looks like he's in his early 30s...

Did Alex Jones write this? The prophet tried to warn us. Another conspiracy theory confirmed. It is a challenge to read everyone’s book, take everyone’s classes, listen to everyone’s podcast to get the help you need to grow your business. I interview some of the most successful people in the world, whom I call Elite Entrepreneurs. business

Did Chrissy Teigen write this? JackOfAllGraves here ya go hashtag eat the fucking rich etc. Lol. Good one Twitter! Countess Erzsebet Bathory has entered the conversation 🤣🤣 Linda_H89 And the poor children kidnapped, raped, beaten and murdered just for this aging miracle. Like Freddy Mercury sings it « Who wants to live forever? » and at what cost seriously? This is crazy shit!!!

Ach, de jeugd is al de dupe van alles, laten we ze hier ook nog even voor misbruiken. sickmind Vampires But young people only get older... Ask johnlegend and his wife Chrissy, they are constantly stealing blood from young children, especially their own! 🐰 Dr. Lewis Thomas pointed out that if you control for infant mortality and childhood infectious disease, the average lifespan hasn't increased all that much. The 'three score and ten' meter comes from Psalms, written 2,500 years ago.

I was right smartass I don't think the oxygen carrying capacity of RBCs diminishes over time. And anyway when it comes to aging oxygen is the enemy these researches have nothing to do with healing but rather another weapon of mass destruction. This should end really well. Always thought there was a vampiric element to the young-old relationship thing.

What the fuck is this? Super not into harvesting blood from let’s face it, poor people, so that rich fucks can potentially live longer and continue to be rich fucks. There’s a screenplay waiting to be written from this post. Lengthen telomeres on chromosomes or prevent the telomeres from shrinking Go ask the elite. They already know. 🥰

I'm sorry, but this sounds like a horror movie I watched in the 1970s... Gotta get a good Bathory reference in here Hummm really. Heard that story before but was deemed a conspiracy theory 🤔 Way to keep conservative doomer cultists fueled up on conspiracy fodder. And here come the Qbots self validating over drinking baby blood.