But the study also found a surprise: Patients who were taking ACE inhibitors appeared to have a survival benefit. Around 3% of the patients who died in the hospital were taking an ACE inhibitor, compared with 9% of those who survived their infections The odds of dying were about two-thirds lower in patients taking ACE inhibitors than those who were not. Taking amedication to control cholesterol was also linked to improved survival, as was female sex.
The study is observational, which means it can’t prove that the medications, alone, were responsible for the benefit. There could be other similarities between patients taking ACE Inhibitors orBut Mehra believes his findings point to a biological effect that may be important in COVID-19 infections. ACE inhibitors may increase ACE2 enzymes -- the doorways the virus uses to attack our cells.
“Each of these studies has weaknesses inherent in observational data, but we find it reassuring that three studies in different populations and with different designs arrive at the consistent message that the continued use of ACE inhibitors and ARBs is unlikely to be harmful in patients with Covid-19,” the comment said.
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