Blood Plasma From Survivors Will Be Given to Coronavirus Patients

Medical Test, Blood Donation, Antibody, Coronavirus, Covıd-19, Quarantines, Hospital, Sars, Your-Feed-Healthcare, Fda, Mount Sinai Medical Center

In people who have recovered, plasma is teeming with antibodies that may fight the virus. But the treatment beginning in New York is experimental.

Medical Test, Blood Donation

27.3.2020

Can blood from coronavirus survivors help other people fight the illness? Doctors in New York will soon be testing the idea in hospitalized patients who are seriously ill.

In people who have recovered, plasma is teeming with antibodies that may fight the virus. But the treatment beginning in New York is experimental.

4:38 p.m. ET Can blood from coronavirus survivors help other people fight the illness? Doctors in New York will soon be testing the idea in hospitalized patients who are seriously ill. Blood from people who have recovered can be a rich source of antibodies, proteins made by the immune system to attack the virus. The part of the blood that contains antibodies, so-called convalescent plasma, has been used for decades to treat infectious diseases, including Ebola and influenza. “It’s kind of difficult scientifically to know how valuable it is in any disease until you try,” said Dr. David L. Reich, president and chief operating officer of the Mount Sinai Hospital, which will be using the treatment. “It’s not exactly a shot in the dark, but it’s not tried and true.” Dr. Reich said it would be tried as a treatment for hospitalized patients who had a moderate form of the disease and had trouble breathing, but not for those who are in advanced stages of the disease. ”The idea is to get to the right patients at the right time,” he said. “But it’s experimental.” Researchers at Mount Sinai were among the first in the United States to develop a test that can detect antibodies in recovering patients, an essential part of this treatment strategy. On Tuesday, the Food and Drug Administration gave permission for the plasma to be used experimentally on an emergency basis to treat coronavirus patients, and hospitals in New York quickly began asking to participate, said Dr. Bruce Sachais, chief medical officer of the New York Blood Center, which will collect, test and distribute the plasma. “Our main focus is, how do we implement this quickly to help the hospitals get product to their patients,” Dr. Sachais said. “We have blood centers in New England, Delaware and the Midwest, so we can do the same thing in other regions. We’re working with other blood centers and hospitals that may collect their own blood and want to do this. We may not be able to collect enough plasma in New York to help the entire country, so we want to share with other centers to help them.” Dr. Reich said that an email asking Mount Sinai staff members who had recovered to consider donating plasma went “a little viral,” and quickly drew 2,000 responses. But volunteers will have to be carefully screened to meet strict criteria. The donors will include people who tested positive for the virus when they were ill, recovered, have had no symptoms for 14 days, now test negative — and have high levels, also called titers, of antibodies that fight the virus. Dr. Reich said that because there were delays and shortages in testing, the number of people who qualify may be low at first. “Our expectation, based on reports from the Chinese experience, is that most people who get better have high-titer antibodies,” Dr. Sachais said. “Most patients who recover will have good antibodies in a month.” People who qualify will then be sent to blood centers to donate plasma. The procedure, called apheresis, is similar to giving blood, except that the blood drawn from the patient is run through a machine to extract the plasma, and the red and white cells are then returned to the donor. Needles go into both arms: Blood flows out of one arm, passes through the machine and goes back into the other arm. The process usually takes 60 to 90 minutes, and can yield enough plasma to treat three patients, Dr. Sachais said. People who have recovered have antibodies to spare, and removing some will not endanger the donors or diminish their own resistance to the virus, Dr. Sachais said. “We may get rid of 20 percent of their antibodies, and a couple days later they’ll be back.” The plasma will be tested to make sure it is not carrying infections like hepatitis or H.I.V., or certain proteins that could set off immune reactions in the recipient. If it passes the tests, it can then be frozen, or used right away. Each patient to be treated will receive one unit, about a cup, which will be dripped in like a blood transfusion. As with blood transfusions, plasma donors and recipients must have matching types, but the rules are not the same as those for transfusions. “We think this is going to be an effective treatment for at least some patients, but we don’t really know yet,” Dr. Sachais said. “Hopefully, we’ll get some data in the next few weeks from the first patients, to see if we’re on the right track.” “In other coronavirus epidemics I don’t think we have strong evidence,” he said. “We don’t have controlled data. There were reports from SARS and MERS that patients improved.” He said the decision to try this approach was based in part on reports from China that it seemed to help patients. But the reports are not based on controlled studies or definitive data. Dr. Sachais said an article in a journal that was not peer-reviewed described treating 10 patients in China with one unit each of convalescent plasma, and said it appeared safe and seemed to quickly lower their virus levels. “It’s anecdotal,” he said. A researcher not associated with the new treatment plans said there was evidence to support using plasma from survivors. “Four to six or eight weeks after infection, their blood should be full of antibodies that will neutralize the virus and that will theoretically limit the infection,” said Vineet Menachery, a virologist at the University of Texas Medical Branch. In studies in mice, he said, “If you can drive the virus replication down tenfold to hundredfold, that can be the difference between life and death.” He described the use of convalescent plasma as “a classic approach that is a really effective way to treat” — if there are enough donors with enough of the right antibodies. A potential risk, he said, is that the patient’s immune system could react against something in the plasma, and cause additional illness. Although hospitals will gather information about the patients being treated, the procedure is not being done as part of a clinical trial. There will not be a placebo group or the other measures needed to determine whether a treatment works. “People are so desperately ill now, it isn’t the right time,” Dr. Reich said. “They’re in the hospital, they’re sick, in intensive care, on ventilators. Some get sick so quickly, and it’s such a severe illness in some people, we feel it’s not the right moment.” He said the doctors were relying on science and evidence as much as possible. But he added: “You see this steamroller coming at you, and you don’t want to sit there passively and let it roll over you. So you put together everything you have to try to fight it. This has the potential to help and also the potential to harm, but we just won’t know until it’s later in the process of the disease and people have had an opportunity to try different things.” Survivors seem eager to help. “We’re getting a lot of requests,” Dr. Sachais said. “One center sent a survey to patients who are getting better, and there were hundreds of responses saying they were interested in being donors. This is going to bring people together. People who’ve survived will want to do something for their fellow New Yorkers.” Advertisement Read more: The New York Times

Excellent idea. I'm so surprised we haven't been doing this already. NB: Please do not speak about tests on animals when you are trying to explain actual science. YOU CANNOT TRANSFER RESULTS FROM ANIMALS TO HUMANS, ANIMALS CANNOT EVEN CATCH THE COVID19, WAKE UP!! NYT is a complete joke, persistent though but sad.

I thought of this idea ages ago, I posted it on FB looks like someone has taken up my plan 🙏🏻 Chinese research has proved that this method is feasible. A survivor can save four people by donating blood. But it's not an absolute antidote, it depends on the situation. I hope it works!!! They watched “Outbreak” (1995)

please refer the Chinese experience Will you stop stealing pics from China A nightmare we are living in 😖 China should know this... but it isn’t sharing with the world. Even it shares the data out of the blue, be cautious and alert! China have done this, doesn’t seem to work...

FDA Eases Blood Plasma Treatment Rule for COVIDAccess to a blood plasma treatment for seriously ill coronavirus patients has been made easier by the U.S. Food and Drug Administration. What to know: 🙏🙏🙏

I earlier have an idea of transmitting Corona treated patient's blood to affected ones for treatment as antibody of treated patient can help! But in India, we've seen a Corona treated patient got Corona affected again. So I am doubtful over this idea!! CNBC BBCWorld ndtv Good point. Find the antibody and test the blood of recovered patients from the flu begun last Sep. Sure there lots samples can be checked.

Hopefully

Can blood from coronavirus survivors treat the newly ill?Hospitals are gearing up to test if a century-old treatment used to fight off flu and measles outbreaks in the days before vaccines, and tried more recently against SARS and Ebola, just might work for COVID-19 , too: using blood donated from patients who’ve recovered. Now a network of U.S. hospitals I hope there are other treatments being looked at, as not everyone can have that. Convalescent plasma products helped with H1N1 and others ... was also used vis polio in the mid stages. Plasma*

FDA Approves Plasma Treatment for Coronavirus on Conditional BasisThe blood plasma of patients who have recovered from Covid-19 will be allowed for conditional use in treating the disease even though the effectiveness is unproven. srqstockpicker This is no brainer IMHO. 「回復期の血漿が研究されたすべての疾患に有効であるとは示されていない」・゜・(つД`)・゜・ :エボラでは上手くいったのに Has china become credible again?🤒 Do you actually believe in the propaganda of the chinese gov?🤪 Can't believe you have fallen so far🤣

FDA says it is expediting the use of a blood plasma treatment as New York begins to roll out new clinical trialsThe US Food and Drug Administration on Tuesday said it is expediting the use of a blood plasma treatment for patients seriously ill with the coronavirus, making it easier for doctors to try another tool to attack the illness. Doctors and State Governors will have to lead us through this thing. The White House is utterly incompetent and overwhelmed The world is finally ONE CHINA!! ccpvirus Blood plasma infected with virus can be replaced with clean blood plasma. If there are sufficient clean blood plasma available, those who are seriously infected can be helped. Take care and survive! Best luck.

Coronavirus and High Blood PressurePeople with high blood pressure may get sicker if infected with coronavirus. How does it affect those with high blood pressure and how can you protect yourself? FInd out here. Well then be happy, I will be gone and enjoy your beautiful community and wife

U.S. companies, labs rush to produce blood test for coronavirus immunityAs the United States works overtime to screen thousands for the novel coronaviru... 'proceed to market without full agency review and approval'—Sounds like Trump's idea of a work-screening test, complete with plenty of false positives for the antibodies and more divisive elements for political advantage: 'Trump's immunity test got me my job back!' blare the ads. LATIN CURSE' WILL FALL ON TRUMP AND THE 'REPUBLICANS' FOR ILL-TREATMENT OF CHILDREN, YOUNG PEOPLE, AND ADULTS, 'LATIN IMMIGRANTS' FOR 'THEFT', 'SANCTIONS', 'BLOCKAGES', TO CUBA AND VENEZUELA, EVIDENTLY WIN OF SANDMARK , RETWITEAR Return to work where.. when EarthIsOnLockdown



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