- A combination of AstraZeneca’s lung cancer drug Imfinzi and an experimental treatment failed to extend the lives of patients with advanced non-small cell lung cancer and high levels of gene mutations, the drugmaker said on Wednesday.
London-listed AstraZeneca said that though the trial involved a wide range of patients, the primary group being tested had high levels of mutations in their DNA.“This is clearly disappointing, albeit we do not think hopes were especially high for the durvalumab plus tremelimumab combination given the relatively poor data shown by the combination to date,” said Liberum analyst Graham Doyle.
Imfinzi, which was the first immunotherapy to be approved in the stage III lung cancer setting, targets the PD-L1 protein on tumor cells, while tremelimumab targets the CTLA-4 protein. AstraZeneca has been seen as having a head start in the race for cancer treatments and sales of those medicines, including Imfinzi, have been key to its turnaround.
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