The cells from different containers connect, the container itself is degradable and eventually disappears.
To prevent this, the research team at TU Wien is working with a new approach: specially developed laser-based high-resolution 3D printing systems are used to create tiny cage-like structures that look like mini footballs and have a diameter of just a third of a millimeter. They serve as a support structure and form compact building blocks that can then be assembled into any shape.
"This is exactly what we have now been able to show for the first time," says Kopinski-Grünwald."Under the microscope, you can see very clearly: neighboring spheroids grow together, the cells migrate from one spheroid to the other and vice versa, they connect seamlessly and result in a closed structure without any cavities -- in contrast to other methods that have been used so far, in which visible interfaces remain between neighboring cell clumps.
A new strategy in tissue engineering has been developed: Tiny spherical microscaffolds are created in a high precision 3D printer. They are cultivated with living cells and then assembled. The cells ...
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