Systemic lupus erythematosus is a prototypic autoimmune disease whose immunological hallmark is the production of antinuclear antibodies.
These bind DNA, RNA and associated proteins, leading to deposition of immune complexes and induction of inflammation, cytokine release and organ damage — with lupus nephritis being among the most serious manifestations.
NatImmunol WeillCornell FabioTorressav doctoravanegas doctorchmunoz elreumatologo
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