Amgen drug shrinks tumors in lung cancer patients with KRAS gene mutation - study

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An experimental Amgen Inc drug that targets a specific genetic mutation shrank tumors in 32% of advanced lung cancer patients and 7% of those with colon cancer, according to data from an early-stage trial presented on Sunday.

FILE PHOTO: An Amgen sign is seen at the company's office in South San Francisco, California in this October 21, 2013 file photo. REUTERS/Robert Galbraith/Files

Patients in the Phase I trial involving several types of cancer were treated with once daily sotorasib. The oral medication is designed to target a mutated form of a gene known as KRAS that occurs in about 13% of non-small cell lung cancers , the most common type of lung cancer. Out of 59 NSCLC patients, 32% had a partial response to the drug - tumor shrinkage by at least 30% - and 88% had either a lesser response or stable disease. For the 42 patients with colorectal cancer, 7% had tumor shrinkage and 74% had stable disease.

The company expects by the end of this year to have results from a mid-stage lung cancer trial that could be used to seek U.S. approval of sotorasib.

 

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That’s cool news and a ray of hope for those with KRAS gene mutation. Long term outcome data should be interesting and mortality/morbidity data.

Medical industry and scientists must be ashamed of themselves for not finding the cure for cancer yet. Otherwise, they are not trying to find it on purpose.

5:50 PM · 20 сент. 2020 г.·True Anthem

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