"Analyses at 18 months showed dose- and time-dependent clearance of amyloid with lecanemab, and the drug was associated with less clinical decline on some measures than placebo," the researchers said in the published study. The investigators relied on a tool that measures cognitive impairment. It's called the Clinical Dementia Rating-Sum of Boxes — it follows the participants' progress.
After 18 months of treatment, the average score of the lecanemab group went up by 1.21 points, compared to patients in the placebo group — who saw their score go up by 1.66 points. Some participants did experience adverse events, the researchers noted. Said one leading expert in Alzheimer's about the new findings, "We have a lot of ground to cover to get from the 27% slowing [that] lecanemab offers to our goal of slowing cognitive decline by 100%."
The organization also noted, in part,"These peer-reviewed, published results show lecanemab will provide patients more time to participate in daily life and live independently. It could mean many months more of recognizing"Statistically significant does not always mean practically significant, especially not in the setting of significant risks."
"The FDA is expected to decide whether to grant accelerated approval to lecanemab by January 6, 2023," said the Alzheimer's Association.
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