Alabama doctors advance organ transplantation with gene-edited pig kidneys

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The surgery marked the second time a pig kidney had been implanted in a brain-dead person. The first took place five days earlier at NYU Langone Health in New York City.

as a last-ditch effort to save his life.

At UAB Hospital, the recipient, Jim Parsons, 57, had been declared brain dead but was maintained on a ventilator. Parsons, of Huntsville, Alabama, was involved in a dirt bike accident in late September that left him unable to recover.His organs were not viable for donation, but his family allowed his body to be used in the study.

“I didn’t realize how thankful I was for that trip until after he passed away," his son David said in a statement released by the hospital. “That was a trip he wanted to take us on his whole life, and I’m thankful for it.”In the operation Sept. 30, Jim Parsons' kidneys were replaced with two from a gene-edited pig raised in a pathogen-free facility established by UAB.

A surgical team prepares the abdomen of a brain-dead recipient for xenotransplantation at the UAB Hospital.So-called xenotransplantations are intended to help solve the human organ shortage. People in need of a heart, kidney or other organ often have to wait years, if they get one at all. Their second chance comes at the expense of someone else, who had to die and donate organs.

UAB has a particular interest in solving the organ crisis because the hospital is located in the "stroke belt," and many of its patients are minorities, Dr. Selwyn Vickers, dean of the UAB Heersink School of Medicine, said Tuesday. UAB, he said, has performed more organ transplants in Black Americans than any other institution and the second highest number of transplants overall in the past 30 years.

Selwyn Vickers, dean of the UAB Heersink School of Medicine, says UAB Hospital has performed more organ transplants in Black Americans than any other institution.

 

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